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【medical-news】睡眠性呼吸暂停可能会触发夜间心
NEW YORK (Reuters Health) - The blood pressure, nerve, and hormonal changes wrought by obstructive sleep apnea (OSA) may increase the risk of heart attack during the night, new research suggests.
OSA is a common problem in which tissues in the back of the throat temporarily collapse during sleep causing numerous, brief episodes of interrupted breathing. The condition, which can cause extreme daytime sleepiness, can be effectively treated with a special breathing device that alleviates the blockage by pushing air into throat.
The body changes that occur with OSA may lead to blockage of the coronary arteries and heart attack, Dr. Virend K. Somers and associates explain in the Journal of the American College of Cardiology. If OSA is a trigger for a heart attack, a peak of heart attack symptoms would be expected during the night.
To investigate this premise, Somers at the Mayo Clinic in Rochester, Minnesota, and colleagues studied 92 heart attack patients in whom the time the chest pain began could be documented. The patients underwent overnight sleep tests 2 to 3 weeks after their heart attack.
OSA was identified in 64 patients (70 percent). Those with and without OSA were generally similar in terms of their health background and current medications.
From midnight to 6 am, the frequency of heart attack was higher in OSA patients, whereas from 6 am to noon, it was higher in patients without OSA. All told, patients with OSA were 6-times more likely to have to have a heart attack at night compared with patients without OSA.
These findings suggest that nighttime heart attacks may contribute to the increased likelihood of nighttime sudden death that has been reported in OSA patients, Somers' group concludes.
The researchers recommend that patients with a heart attack at night be evaluated for OSA.
SOURCE: Journal of the American College of Cardiology, July 2008.
http://www.reuters.com/article/healthNews/idUSTON17669520080721 睡眠性呼吸暂停可能会触发夜间心脏病发作
纽约（路透社 健康）新近研究发现，阻塞性睡眠呼吸暂停（OSA）引起的血压，神经和激素水平变化可能增加心脏病的夜间发作。
OSA是一种常见病，其咽后部组织在睡眠期间发生短暂的塌陷，导致多发的短暂的呼吸暂停。这种情况造成患者白天过度倦怠，通过特殊的呼吸装置向咽部正压送气，可缓解气道阻塞，有效治疗该病。
OSA引起的机体变化可能导致冠状动脉阻塞和心脏病发作，Virend K. Somers和其同事在美国心脏病学院杂志上对此作出了解释。如果OSA是心脏病发作的促发因素，那么心脏病发作的高峰时段应该出现在夜间。
为证明这种假设，Somers和其同事在明尼苏达州罗切斯特的梅奥临床中心研究了92例心脏病发作患者，这些患者的胸痛发作时间均有档案可循。
在心脏病发作后的2到3周，上述患者接受了睡眠监测。
64名患者存在OSA（70%）。这些存在和没有OSA的患者在健康背景和目前用药方面均大致相同。
从午夜到早晨6点，OSA患者的心脏病发作频率更高，而早晨6点到中午，无OSA的患者心脏病发作频率更高。OSA患者与无OSA患者相比，前者夜间心脏病发作频率是后者的6倍。
Somers的研究团队推测，该研究表明，OSA患者夜间猝死增加可能源于夜间的心脏病发作。研究人员建议有夜间心脏病发作的病人应该进行OSA的相关评估。
来源：美国心脏病学院杂志，2008年7月 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-07-22 18:44
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