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【文摘发布】老龄化对脑血流和脑脊液流量的影
Author： Stoquart-Elsankari S, Baledent O, Gondry-Jouet C, Makki M, Godefroy O, Meyer ME.
Resource: J Cereb Blood Flow Metab. 2007 Feb 21; [Epub ahead of print]
Abstract： Phase-contrast magnetic resonance imaging (PC-MRI) is a noninvasive reliable technique, which enables quantification of cerebrospinal fluid (CSF) and total
cerebral blood flows (tCBF). Although it is used to study hydrodynamic cerebral
disorders in the elderly group (hydrocephalus), there is no published evaluation
of aging effects on both tCBF and CSF flows, and on their mechanical coupling.
Nineteen young (mean age 27+/-4 years) and 12 elderly (71+/-9 years) healthy
volunteers underwent cerebral MRI using 1.5 T scanner. Phase-contrast magnetic
resonance imaging pulse sequence was performed at the aqueductal and cervical
levels. Cerebrospinal fluid and blood flow curves were then calculated over the
cardiac cycle, to extract the characteristic parameters: mean and peak flows,
their latencies, and stroke volumes for CSF (cervical and aqueductal) and
vascular flows. Total cerebral blood flow was (P<0.01) decreased significantly
in the elderly group when compared with the young subjects with a linear
correlation with age observed only in the elderly group (R(2)=0.7; P=0.05).
Arteriovenous delay was preserved with aging. The CSF stroke volumes were
significantly reduced in the elderly, at both aqueductal (P<0.01) and cervical
(P<0.05) levels, whereas aqueduct/cervical proportion (P=0.9) was preserved.
This is the first work to study aging effects on both CSF and vascular cerebral
flows. Data showed (1) tCBF decrease, (2) proportional aqueductal and cervical
CSF pulsations reduction as a result of arterial loss of pulsatility, and (3)
preserved intracerebral compliance with aging. These results should be used as
reference values, to help understand the pathophysiology of degenerative
dementia and cerebral hydrodynamic disorders as hydrocephalus.
PMID: 17311079 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title： Aging effects on cerebral blood and cerebrospinal fluid flows.
标题：老龄化对脑血流和脑脊液流量的影响
Author： Stoquart-Elsankari S, Baledent O, Gondry-Jouet C, Makki M, Godefroy O, Meyer ME.
作者：Stoquart-Elsankari S, Baledent O, Gondry-Jouet C, Makki M, Godefroy O, Meyer ME.
Resource: J Cereb Blood Flow Metab. 2007 Feb 21; [Epub ahead of print]
文章来源：脑血流量代谢杂志.2007.2.21;
Abstract： Phase-contrast magnetic resonance imaging (PC-MRI) is a noninvasive reliable technique, which enables quantification of cerebrospinal fluid (CSF) and total cerebral blood flows (tCBF).
摘要：
相位对比磁共振影像学（PC-MRI）是一种可靠的无创技术，其可以对脑脊液（CSF）及脑总血流量(tCBF)进行定量。
Although it is used to study hydrodynamic cerebral disorders in the elderly group (hydrocephalus), there is no published evaluation of aging effects on both tCBF and CSF flows, and on their mechanical coupling.
虽然这种技术通常用来研究老年人的流体性脑功能障碍（脑积水），但没有公开的关于老龄化对tCBF和CSF流量的影响及对其耦合的评价。
Nineteen young (mean age 27+/-4 years) and 12 elderly (71+/-9 years) healthy volunteers underwent cerebral MRI using 1.5 T scanner.
19名年轻（平均年龄为27+/-4岁）及12名年纪较大的（71+/-9岁）健康志愿者使用1.5T扫描仪进行大脑MRI检查。
Phase-contrast magnetic resonance imaging pulse sequence was performed at the aqueductal and cervical levels.
对血管和脊神经进行连续脉冲的相位对比磁共振影像术检测。
Cerebrospinal fluid and blood flow curves were then calculated over the cardiac cycle, to extract the characteristic parameters: mean and peak flows, their latencies, and stroke volumes for CSF (cervical and aqueductal) and vascular flows.
然后根据心搏周期描绘脑脊液和血流曲线，来推断特性参数：平均流量和峰流量，其达峰时间及CSF（脊神经和血管）和脑血管的每搏量。
Total cerebral blood flow was (P<0.01) decreased significantly in the elderly group when compared with the young subjects with a linear correlation with age observed only in the elderly group (R(2)=0.7; P=0.05).
与年轻受试者相比，老年组的脑总血流量明显下降(P<0.01)，且仅老年组出现脑总血流量与年龄的线性相关(R(2)=0.7; P=0.05)。
Arteriovenous delay was preserved with aging. The CSF stroke volumes were significantly reduced in the elderly, at both aqueductal (P<0.01) and cervical (P<0.05) levels, whereas aqueduct/cervical proportion (P=0.9) was preserved.
随着年龄增长仍维持动静脉延搁。老年组的血管(P<0.01)和脊神经(P<0.05) CSF每搏量都明显减少，然而仍维持脉管/脊神经的比例(P=0.9)。
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作者:admin@医学,生命科学 2011-07-05 05:52
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