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有丝分裂：可视化

有丝分裂的机理研究一直是研究的热点，这篇报道的最大意义在于采用了荧光探针，使细胞的有丝分裂过程真实地呈现在大家的面前，这一技术给今后的细胞内更多活动的可视化研究带来冲击。

Familiarity with the exact timing of cell-cycle events is important for understanding disease mechanisms and for determining the effects of drugs on the cell cycle. In this month's Nature Biotechnology, Joshua Jones and colleagues have engineered a new fluorescent biosensor that enables mitosis to be monitored simultaneously in a large number of cells. A shuttling fluorescent protein allows the time between nuclear-envelope breakdown and reformation to be tracked precisely in up to several hundred cells at once. Conly Rieder and Alexei Mikhailov review the work in an accompanying News and Views article.

article

Probing the precision of the mitotic clock with a live-cell fluorescent biosensor

J. T. JONES et al.

Nature Biotechnology 22, 306; March 2004 [标签:content1][标签:content2]

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作者:admin@医学,生命科学    2011-06-15 05:20
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