主页 > 医学文档 >

【medical-news】甲状腺癌方面的新发现指出了新的

http://qnc.queensu.ca/story_loader.php?id=455b19ea90034

Thyroid cancer discovery points to new treatments, prevention
Wednesday November 15, 2006

The actions of a mutated protein in cells linked to thyroid cancer have been uncovered by researchers at Queen’s University. The discovery paves the way for the future development of drugs to more effectively target, treat and possibly even prevent both inherited and non-inherited thyroid cancers.

“We now know why this gene causes these tumours and can start looking at how best to target the mutant proteins so that the cells expressing them can be killed or stopped from growing,” says Lois Mulligan, professor of pathology and molecular medicine with the Division of Cancer Biology and Genetics of the Queen’s Cancer Research Institute. She is senior author of a study to be published November 15 in the journal Cancer Research.

Taranjit S. Gujral, a Ph D student in Queen’s Department of Pathology and Molecular Medicine and lead author on the paper, developed three-dimensional models of the mutated RET protein implicated in a condition causing cancerous thyroid tumours. The model allowed him to predict and compare the protein’s molecular actions and to see that the protein was ten times more active than normal in cells associated with Multiple Endocrine Neoplasia 2B (MEN 2 syndrome, an inherited cancer syndrome. Co-authors on the study include Vinay K. Singh and Zongchao Jia of Queen’s Biochemistry Department.

“It’s like stepping on the gas in a car and getting way more gas than you bargained for,” says Mulligan. “The mutation may cause some new actions but it chiefly does some actions more efficiently than normal.”

MEN 2B is a dominantly inherited condition – the most severe of its kind – and is characterized by the early onset of thyroid tumours, sometimes even affecting infants, and can also cause developmental abnormalities including elongated bones, gastric problems and bumpy lips.

MEN 2B is currently treated with surgery, and other treatments, such as radiation and chemotherapy are not very effective. The study provides valuable tools for specific targeting of the actions of the protein that may aid in the development of anticancer therapies.

The models created by Mr. Gujral, a Canadian Institutes of Health Research (CIHR) Trainee in Transdisciplinary Cancer Research and Protein Function Discovery, can be used further to help illuminate the actions of the protein with MEN 2B’s other mutations. The research team credits the transdisciplinary approach and its benefits for providing fresh perspectives in generating the new understanding of RET’s role in MEN 2B. Additional funding for the study came from the Canadian Cancer Society and the CIHR. 本人已认领该文编译,48小时后若未提交译文,请其他战友自由认领。 Thyroid cancer discovery points to new treatments, prevention
Wednesday November 15, 2006
甲状腺癌方面的新发现指出了新的治疗和预防途径
2006年11月15日,星期三

The actions of a mutated protein in cells linked to thyroid cancer have been uncovered by researchers at Queen’s University. The discovery paves the way for the future development of drugs to more effectively target, treat and possibly even prevent both inherited and non-inherited thyroid cancers.
女皇大学的研究人员们已揭示了与甲状腺癌相关细胞突变蛋白的作用。该发现为未来开发更加靶向的,甚至能治愈遗传性和非遗传性甲状腺癌的药物铺平了道路。

“We now know why this gene causes these tumours and can start looking at how best to target the mutant proteins so that the cells expressing them can be killed or stopped from growing,” says Lois Mulligan, professor of pathology and molecular medicine with the Division of Cancer Biology and Genetics of the Queen’s Cancer Research Institute. She is senior author of a study to be published November 15 in the journal Cancer Research.
“我们现在知道为什么该基因能引起这些肿瘤,并且能够开始关注如何将这些突变蛋白作为最佳的靶点,以杀死表达它们的细胞或阻止其生长。”女皇大学癌症研究所肿瘤生物与遗传学教研室的病理学和分子医学教授Lois Mulligan说道。

Taranjit S. Gujral, a Ph D student in Queen’s Department of Pathology and Molecular Medicine and lead author on the paper, developed three-dimensional models of the mutated RET protein implicated in a condition causing cancerous thyroid tumours. The model allowed him to predict and compare the protein’s molecular actions and to see that the protein was ten times more active than normal in cells associated with Multiple Endocrine Neoplasia 2B (MEN 2 syndrome, an inherited cancer syndrome. Co-authors on the study include Vinay K. Singh and Zongchao Jia of Queen’s Biochemistry Department.

阅读本文的人还阅读:

【转贴】中国研制出新型

IκB Kinase 促进肿瘤发生的

【bio-news】本周细胞杂志

【bio-news】基因缺失引发

【社会人文】新计划将为

作者:admin@医学,生命科学    2011-05-28 17:11
医学,生命科学网