主页 > 医学文档 >
创伤愈合基因可促进肿瘤转移
创伤愈合和肿瘤进展有一些相似点，包括新生血管的生长、细胞周围分子基质的重排和细胞之间粘附方式发生变化等。因此Chang等首先在暴露于血凝块的细胞（作为创伤愈合过程中的细胞模型）中找到功能活跃的基因，然后再检测这些基因在肿瘤样本中是否也有表达。结果显示，这些基因在乳腺癌、肺癌和胃癌等肿瘤的临床早期有明显表达，在治疗期持续存在，并且预示着肿瘤转移和死亡的危险升高。
由于目前对创伤愈合的过程已很了解，因此通过阻断该过程可减慢肿瘤的转移速度，最终将找到治疗肿瘤的新方法。
PLoS Biol. 2004 Jan 13;2(2):E7.
Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds.
Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K, Chi JT, Rijn Mv M, Botstein D, Brown PO.
Department of Dermatology, Stanford University School of Medicine, Stanford, California, United States of America.
Cancer invasion and metastasis have been likened to wound healing gone awry. Despite parallels in cellular behavior between cancer progression and wound healing, the molecular relationships between these two processes and their prognostic implications are unclear. In this study, based on gene expression profiles of fibroblasts from ten anatomic sites, we identify a stereotyped gene expression program in response to serum exposure that appears to reflect the multifaceted role of fibroblasts in wound healing. The genes comprising this fibroblast common serum response are coordinately regulated in many human tumors, allowing us to identify tumors with gene expression signatures suggestive of active wounds. Genes induced in the fibroblast serum-response program are expressed in tumors by the tumor cells themselves, by tumor-associated fibroblasts, or both. The molecular features that define this wound-like phenotype are evident at an early clinical stage, persist during treatment, and predict increased risk of metastasis and death in breast, lung, and gastric carcinomas. Thus, the transcriptional signature of the response of fibroblasts to serum provides a possible link between cancer progression and wound healing, as well as a powerful predictor of the clinical course in several common carcinomas.
医学空间《新闻中心》 [标签:content1][标签:content2]
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-04-27 05:11
医学,生命科学网