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【medical-news】阿米洛利：除了降压还能治疗多发
A drug currently used to treat high blood pressure and heart failure has been found to reduce the symptoms of multiple sclerosis in mice. The discovery that amiloride can reduce the degeneration of nerve tissue in mice suggests it could have a therapeutic potential for people who have MS. However, despite the positive findings, the researchers warn that clinical trials in people, to test the drug's full potential, are crucial before it is given as a treatment for the disease.
The research led by Professor Lars Fugger of the Medical Research Council Human Immunology Unit and Department of Clinical Neurology at Oxford University is published in Nature Medicine. Professor Fugger said:
''This drug [amiloride] is already licensed for another purpose. Looking for new ways to use established drugs is usually cheaper than starting the discovery process from scratch, we've had a really positive result.''
The search for therapeutic potential began with studies of the role of a channel called ASIC1 that creates an opening in the cell membrane. ASIC1 works by sensing acid levels around the cell and lets sodium and calcium molecules into cells. This process is an important part of the process of sensing pain and touch. Using mice with a condition that mimics some aspects of the human form of multiple sclerosis the scientists found that the ASIC1 channel also contributes to degeneration of the axon, the long stem of the nerve. When the channel remains open, sodium and calcium can flood into the cell in higher than normal proportions.
Professor Fugger explained:
''When sodium and calcium levels accumulate in excessive proportions within nerve cells, the axon, the bit that carries messages from one nerve to the next, is damaged. We found that this damage was reduced in mice given amiloride. The drug appears to work by blocking the action of the channel that lets sodium and calcium molecules into the cell.''
The research has shown that not only is the ASIC1 channel a suitable target for drugs that aim to protect against neurodegeneration in research but that amiloride might be beneficial in treatment.
Overall this suggests that drugs targeted at the ASIC1 channel, like amiloride, could help reduce the level of nerve damage caused by multiple sclerosis. The research team are now beginning to plan a clinical trial that will aim to find out if amiloride is beneficial in treating the symptoms of multiple sclerosis in people.
Original research paper: Acid-sensing ion channel 1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system is published in Nature Medicine.
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New Target For MS Treatment Found Using Old Drug
老药新用，治疗多发性硬化
阿a阿啊利：除了降压还能治疗多发性硬化
A drug currently used to treat high blood pressure and heart failure has been found to reduce the symptoms of multiple sclerosis in mice.
当前常用于治疗高血压和心力衰竭的一种药物可以减轻小鼠多发性硬化的症状。
The discovery that amiloride can reduce the degeneration of nerve tissue in mice suggests it could have a therapeutic potential for people who have MS.
盐酸阿米洛利能减轻小鼠神经组织的变形的发现提示盐酸阿米洛利治疗人类的多发性硬化可能。
However, despite the positive findings, the researchers warn that clinical trials in people, to test the drug's full potential, are crucial before it is given as a treatment for the disease.
然而，尽管这些积极的发现，研究人员警告说：人类的临床试验在它被用于治疗人类的疾病之前，检测药物的全部潜能是关键的。
The research led by Professor Lars Fugger of the Medical Research Council Human Immunology Unit and Department of Clinical Neurology at Oxford University is published in Nature Medicine.
这个研究小组是由牛津大学的人类免疫医学研究委员和临床神经病学的Lars Fugger教授领导的，研究成果将在自然医学杂志上发表。
Professor Fugger said: Fugger教授说：
''This drug [amiloride] is already licensed for another purpose. Looking for new ways to use established drugs is usually cheaper than starting the discovery process from scratch, we've had a really positive result.''
盐酸阿米洛利这个药物是已经被批准用于其他治疗目的的。
寻找老的药物新用途通常是比开发新药要节省的多。我们已经有了真实可喜的结果
The search for therapeutic potential began with studies of the role of a channel called ASIC1 that creates an opening in the cell membrane.
治疗潜能的研究开始的研究途径称为ASIC1－在细胞膜上开一个洞。
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作者:admin@医学,生命科学 2011-04-07 18:32
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