主页 > 医学文档 >
【medical-news】无症状的动脉粥样硬化也会增加房
27 February 2007
People who have atherosclerosis without manifest atherosclerotic disease have an increased risk of atrial fibrillation, say Dutch scientists.
They add that their data shows asymptomatic atherosclerosis should be treated "aggressively."
While it is known that myocardial infarction is an important risk factor for atrial fibrillation, the effect of subclinical atherosclerosis is less clear, explains Jacqueline Witteman, from Erasmus Medical Center in Rotterdam, and colleagues.
To investigate further, the team examined data on 4407 participants of the Rotterdam Study aged 55 years or older who did not have atrial fibrillation at baseline, a history myocardial infarction, or angina pectoris, and had not undergone cardiac operative procedures.
As indices of generalized atherosclerosis, the team recorded the baseline intima-media thickness of the common carotid artery and the presence of carotid plaques using ultrasonography.
In all, 269 cases of incident atrial fibrillation were identified over an average follow-up of 7.5 years.
The researchers report in the Archives of Internal Medicine that confounding factors included body mass index, hypertension, systolic blood pressure, serum cholesterol level, smoking, diabetes mellitus, left ventricular hypertrophy on the electrocardiogram, and the use of cardiac medication.
After accounting for these factors, the average intima-media thickness was 0.84 mm in men and 0.80 mm in women, while the median was 0.82 mm in men and 0.78 mm in women. Overall, 40.1% of men and 47.0% of women had no carotid plaques, while 26.6% of men and 18.7% of women had severe disease.
Comparing the highest and lowest quartiles of carotid intima-media thickness, the researchers found that the relative risk of atrial fibrillation, after adjusting for all potential confounding factors, was 1.90 overall, which broke down to 1.61 in men and 2.14 in women. The relative risk of atrial fibrillation among patients with severe carotid plaques in comparison with those without any plaques was 1.49 overall, which broke down to a nonsignificant 1.12 in men and 1.84 in women.
"In conclusion, in this prospective, population-based study, we found that measures of generalized atherosclerosis predict the onset of atrial fibrillation in persons without obvious coronary heart disease," the team writes.
"The findings suggest that aggressive management of atherosclerotic vascular disease, including in asymptomatic subjects, may help to prevent atrial fibrillation."
Arch Intern Med 2007; 167: 382–387
http://www.incirculation.net/NewsItem/Subclinical-atherosclerosis-predicts-atrial-fibril.aspx 本人已认领此文,48小时内交稿 Subclinical atherosclerosis predicts atrial fibrillation
亚临床动脉粥样硬化预示房颤
27 February 2007
2007年2月27日
People who have atherosclerosis without manifest atherosclerotic disease have an increased risk of atrial fibrillation, say Dutch scientists.
荷兰学者表示，已有动脉粥样硬化病变但未被诊断患有动脉粥样硬化疾病的人们患房颤的风险更高。
They add that their data shows asymptomatic atherosclerosis should be treated "aggressively."
他们说其实验数据表明无症状动脉粥样硬化（动粥）应进行积极治疗。
While it is known that myocardial infarction is an important risk factor for atrial fibrillation, the effect of subclinical atherosclerosis is less clear, explains Jacqueline Witteman, from Erasmus Medical Center in Rotterdam, and colleagues.
来自鹿特丹伊拉兹马斯医学中心的Jacqueline Witteman及其同事解释说：我们知道，心肌梗死是房颤的一个重要危险因素，然而亚临床动粥的作用却并不清楚。
To investigate further, the team examined data on 4407 participants of the Rotterdam Study aged 55 years or older who did not have atrial fibrillation at baseline, a history myocardial infarction, or angina pectoris, and had not undergone cardiac operative procedures.
为进一步研究，该小组查看了鹿特丹实验的数据，该实验对象为4407名55岁以上无基础房颤、心肌梗死或心绞痛病史并未做过心脏手术的病人。
As indices of generalized atherosclerosis, the team recorded the baseline intima-media thickness of the common carotid artery and the presence of carotid plaques using ultrasonography.
研究小组使用超声扫描技术记录了正常颈动脉内膜中层的基线厚度，以及颈动脉斑块的存在，作为一般动脉硬化症的指标。
In all, 269 cases of incident atrial fibrillation were identified over an average follow-up of 7.5 years.
经过平均7.5年的随访，确认发生了总计269例房颤事件。
The researchers report in the Archives of Internal Medicine that confounding factors included body mass index, hypertension, systolic blood pressure, serum cholesterol level, smoking, diabetes mellitus, left ventricular hypertrophy on the electrocardiogram, and the use of cardiac medication.
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-02-27 17:12
医学,生命科学网