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【medical-news】胰岛素抵抗是HCV感染的特殊表现
NEW YORK (Reuters Health) - Insulin resistance, a "prediabetic" abnormality of blood sugar, is a specific feature of chronic hepatitis C virus (HCV) infection, independent of the severity of HCV or the presence of other metabolic factors, French investigators report.
HCV infection is now recognized as a system-wide disease, Dr. Rami Moucari, of Universite Denis Diderot-Paris, and colleagues note in a report in the journal Gastroenterology. Some previous studies have linked HCV infection to an increased risk of insulin resistance or full-blown diabetes.
Insulin is the body's key blood sugar-regulating hormone. Normally, insulin is secreted to clear glucose (sugar) from the blood and deposit into cells to use as fuel. Insulin resistance occurs when cells become desensitized to insulin.
In their study, Moucari's team found that 150 (32.4 percent) of 462 chronic HCV patients who did not have diabetes were insulin resistant. In this group, insulin resistance was associated with the metabolic syndrome (a cluster of heart disease and diabetes risk factors), as well as HCV genotypes 1 and 4, significant liver scarring or "fibrosis," severe fatty liver disease, and being older than age 40.
Among 145 chronically HCV infected patients without metabolic syndrome or significant fibrosis, insulin resistance was diagnosed in 22 (15 percent). Insulin resistance in this population was also associated with infection with HCV genotypes 1 and 4, high blood levels of HCV, and moderate-to-severe liver inflammation.
"Insulin resistance should be assessed in the routine management of patients with chronic hepatitis C," Moucari noted in an interview with Reuters Health.
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Insulin resistance tied to hepatitis C infection
胰岛素抵抗与丙肝感染
NEW YORK (Reuters Health) - Insulin resistance, a "prediabetic" abnormality of blood sugar, is a specific feature of chronic hepatitis C virus (HCV) infection, independent of the severity of HCV or the presence of other metabolic factors, French investigators report.
纽约（路透社健康）-法国研究者报导，一种糖尿病前期的血糖异常：胰岛素抵抗，是慢性丙型肝炎（HCV）感染的一种特殊特征，且不依赖于HCV的严重程度或者是否合并其它的代谢因素。
HCV infection is now recognized as a system-wide disease, Dr. Rami Moucari, of Universite Denis Diderot-Paris, and colleagues note in a report in the journal Gastroenterology. Some previous studies have linked HCV infection to an increased risk of insulin resistance or full-blown diabetes.
目前认为HCV感染是一种系统性疾病，巴黎Denis Diderot大学的Rami Moucari博士和他的同事们在《Gastroenterology》上的一篇文献报导，一些前期的研究已经认为HCV感染与胰岛素抵抗的风险增加和糖尿病的发展相关。
Insulin is the body's key blood sugar-regulating hormone. Normally, insulin is secreted to clear glucose (sugar) from the blood and deposit into cells to use as fuel. Insulin resistance occurs when cells become desensitized to insulin.
胰岛素是体内关键的血糖调节激素。正常情况下，胰岛素的分泌会导致血液中葡萄糖（血糖）的降低，而进入细胞中降解为机体提供能量。当细胞对胰岛素不敏感的时候就发生了胰岛素抵抗。
In their study, Moucari's team found that 150 (32.4 percent) of 462 chronic HCV patients who did not have diabetes were insulin resistant. In this group, insulin resistance was associated with the metabolic syndrome (a cluster of heart disease and diabetes risk factors), as well as HCV genotypes 1 and 4, significant liver scarring or "fibrosis," severe fatty liver disease, and being older than age 40.
Moucari的科研小组发现，在他们的研究中，462个慢性HCV病人中有150个（32.4%）未患糖尿病者亦有胰岛素抵抗。在这群人中，胰岛素抵抗与代谢综合征（一群心脏疾病和糖尿病的危险因素），HCV基因型1和4，显著的肝脏瘢痕化或纤维化，严重的脂肪肝，和年龄大于40岁相关。
Among 145 chronically HCV infected patients without metabolic syndrome or significant fibrosis, insulin resistance was diagnosed in 22 (15 percent). Insulin resistance in this population was also associated with infection with HCV genotypes 1 and 4, high blood levels of HCV, and moderate-to-severe liver inflammation.
在145个没有代谢综合征或者显著的肝纤维化的慢性HCV感染病人中，有22人被诊断为胰岛素抵抗（15%）。这些人群中的胰岛素抵抗被认为与HCV基因型1和4型的感染，血液中的高HCV水平，和中等到严重的肝脏炎症相关。
"Insulin resistance should be assessed in the routine management of patients with chronic hepatitis C," Moucari noted in an interview with Reuters Health.
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作者:admin@医学,生命科学 2011-02-27 05:14
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