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【drug-news】抗氧化剂或可提高不育男性的生育能
抗氧化剂或可提高不育男性的生育能力
Antioxidant supplements may benefit couples who have difficulty conceiving naturally, according to a new systematic review published today in The Cochrane Library. The review provides evidence from a small number of trials that suggest the partners of men who take antioxidants are more likely to become pregnant.
Male subfertility affects one in 20 men. Chemicals called reactive oxygen species (ROS) are said to cause damage to cells, and in particular sperm cells, which may result in lowered sperm counts and interfere with their ability to fertilise eggs. Antioxidants include natural and synthetic chemicals, including certain vitamins and minerals, which help to reduce the damage caused by ROS.
The review focused on 34 trials involving 2,876 couples undergoing assisted reproductive techniques such as in vitro fertilisation and sperm injections. Most men in the trials had low sperm counts or low sperm motility. The trials explored the use of many different types of oral antioxidants, including vitamin E, L-carnitine, zinc and magnesium.
Compared to controls, a couple was more likely to have a pregnancy or live birth if the man took antioxidants. However, these results are based on just 964 of the couples in the review for pregnancies and 214 couples for live births. Other trials tested the effects of antioxidants on sperm motility and concentration and showed mostly positive effects, although study group sizes were small.
"When trying to conceive as part of an assisted reproductive program, it may be advisable to encourage men to take oral antioxidant supplements to improve their partners' chances of becoming pregnant," said lead researcher Marian Showell, who works in Obstetrics and Gynaecology at the University of Auckland in Auckland, New Zealand. "However, these conclusions are currently based on limited evidence."
There were not enough data comparing different antioxidants to reach any conclusions about the relative effectiveness of supplements. "We need more head-to-comparisons to understand whether any one antioxidant is performing better than any other," said Showell. Antioxidants May Improve Chances Of Conceiving In Male Subfertility
抗氧化剂或可提高低生育力男性的生育能力
Antioxidant supplements may benefit couples who have difficulty conceiving naturally, according to a new systematic review published today in The Cochrane Library. The review provides evidence from a small number of trials that suggest the partners of men who take antioxidants are more likely to become pregnant.
根据最新发表者在Cochrane图书馆上的一篇系统综述显示，抗氧化剂的补充可使那些自然受孕困难的夫妇获益。这篇综述从小量的临床试验结果中证实到服用抗氧化剂的男性，他们的妻子怀孕的可能性会更高。
Male subfertility affects one in 20 men. Chemicals called reactive oxygen species (ROS) are said to cause damage to cells, and in particular sperm cells, which may result in lowered sperm counts and interfere with their ability to fertilise eggs. Antioxidants include natural and synthetic chemicals, including certain vitamins and minerals, which help to reduce the damage caused by ROS.
20名男性中就有一名生育力低下。一种叫做活性氧族的化学物质据说能引起细胞损害，尤其是精子细胞，这种损害能导致少精症及干扰精子受精的能力。抗氧化剂，包括天然的或合成的化合物，例如某些维生素和矿物质，都能有助于减少由活性氧族带来的危害。
The review focused on 34 trials involving 2,876 couples undergoing assisted reproductive techniques such as in vitro fertilisation and sperm injections. Most men in the trials had low sperm counts or low sperm motility. The trials explored the use of many different types of oral antioxidants, including vitamin E, L-carnitine, zinc and magnesium.
综述归纳了34项临床试验，研究了2876对夫妇，他们分别接受了各种不同的辅助生殖技术，包括体外受精和精子植入。受试这中，大部分男性都患有少精症或者弱精症。试验采用了很多不同种类的口服抗氧化剂，包括维生素E、左旋肉碱、锌以及镁。
Compared to controls, a couple was more likely to have a pregnancy or live birth if the man took antioxidants. However, these results are based on just 964 of the couples in the review for pregnancies and 214 couples for live births. Other trials tested the effects of antioxidants on sperm motility and concentration and showed mostly positive effects, although study group sizes were small.
相比对照组，如果男方服用抗氧化剂，那么他的妻子怀孕或者活产的可能性会更高。当然，这些结果仅仅是建立在964对受孕的夫妇和214对顺利活产的夫妇为基础上的。其它试验测试了抗氧化剂对精子活力和浓度的影响，显示了大部分阳性结果，尽管研究的群体较小。
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作者:admin@医学,生命科学 2011-01-23 00:54
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