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【J Clin Oncol】Pathology：第四军医大学发现一种新
据了解，该肿瘤由第四军医大学基础部病理学与病理生理学教研室王哲、黄高昇两位教授领衔的科研团队发现，并将其命名为“炎症性单形性未分化肉瘤”。所撰写的论文，已经全文发表在肿瘤学国际权威杂志临床肿瘤学(《J Clinical Oncology》)上。
据介绍，该肿瘤常发生于年轻患者的骨和软组织，患者临床表现为疼痛性肿物生长，肿物局部有红、肿、热、痛等化脓性炎症，伴有全身发热、白细胞升高的化脓性炎症表现。
肿瘤形态非常特殊，由单一的胞浆丰富的上皮样细胞组成，胞浆嗜酸性，胞膜明显；泡状肿瘤细胞核大、圆形或卵圆形，染色质开放，具有巨大的嗜酸性核仁；肿瘤中可见大量的嗜中性粒细胞浸润，并有许多微脓肿形成。该肿瘤生长迅速，早期发生局部复发和淋巴结转移，对多种化疗方案无反应，患者均在发病后4月内死于广泛转移和严重并发症。肿瘤局部可穿刺抽出脓液，但多种微生物培养均为阴性结果，多种抗生素治疗无效。通过免疫组化和电镜等技术，未能发现肿瘤细胞特异的分化。
王哲说，炎症性单形性未分化肉瘤的临床表现、病理学形态和预后特征独特，与目前已发现的肿瘤都不相同，在世界卫生组织的肿瘤病理学分类中没有相似类型。澳大利亚皇家病理学院的官方病理专业杂志对此次新肿瘤类型的发现进行了报道。
肿瘤类型是由第四军医大学首次发现并命名的，具有自主知识产权，是我国病理界学者首个自主发现和命名的新的肿瘤类型。 Pathology doi: 10.1097/PAT.0b013e328340c1f4
Inflammatory monomorphic undifferentiated sarcoma with distinct clinical and pathological features: a ‘new’ entity?
Wang, Zhe*,||; Huang, Gaosheng*,||; Yan, Qingguo*; Wang, Lu*; Zhu, Jin*; Lu, Yang*; Li, Peifeng*; Cheng, Hong*; Ma, M Joe?; Walker, Bruce F?; Allen, Philip W§
Abstract
Aim: To describe two patients with a highly aggressive, apparently ‘new’ and rare soft tissue and bone malignancy of childhood and early adult life that we have named inflammatory monomorphic undifferentiated sarcoma.
Methods and results: Two histologically identical tumours located in the proximal humerus and the anterior chest wall of males aged 6 and 31 presented as solitary, painful, tender, necrotising, masses, associated with fever, leukocytosis and negative microbiological cultures. The extensively necrotic resected tumours consisted of large, monomorphic epithelioid cells with vesicular nuclei, prominent eosinophilic nucleoli, and abundant eosinophilic cytoplasm surrounded by numerous neutrophils and eosinophils which formed sterile microabscesses. Immunohistochemical and ultrastructural studies revealed no specific differentiation. Both tumours were very aggressive, with early local recurrence, metastasis to regional and distant lymph nodes and viscera, and no response to several different chemotherapeutic regimens.
Conclusion: A careful review of the literature led us to believe that inflammatory monomorphic undifferentiated sarcoma may represent a rare and distinct clinicopathological entity that does not appear to have been previously described. 厉害啊 肿瘤类型是由第四军医大学首次发现并命名的，具有自主知识产权，是我国病理界学者首个自主发现和命名的新的肿瘤类型。
这个是“自主知识产权”？呵呵，可以专利？ 恭喜恭喜！中国也有原创了！ 支持原创 呵呵~赞一个，我们学校的：） 答案分类平台者:罗淑荣著者单位:第四军医大学唐都医院超声诊断科出 处:心血管病学进展 2000.01.15; ... Toutouzas-P; Camm-AJ SO: Pacing-Clin-Electrophysiol. 1998 Apr; 21(4 Pt 1): 728-...lib.shsmu.edu.cn/...fldAuto=13-2004-07-19-快照-类平台"[标签:content2]
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作者:admin@医学,生命科学 2011-01-18 23:30
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