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【Atherosclerosis 】基因和环境因素对中年男性双胞
Genetic and environmental influences on systemic markers of inflammation in middle-aged male twins
Abstract
Objectives
The aims of this study were to determine the relative influence of genetic and environmental contributions to inflammatory biomarkers, and to what extent correlations among these markers are due to genetic or environmental factors.
Methods
We performed univariate and multivariate genetic analyses of four inflammatory markers: interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), C-reactive protein (CRP), and fibrinogen, in 166 (88 monozygotic and 78 dizygotic) middle-aged male twin pairs.
Results
The mean age (±S.D.) of the twins was 54 (±2.93) years. Heritability was substantial for CRP (0.61, 95% CI: 0.47–0.72) and moderate to fair for IL-6 (0.31, 0.13–0.46), sIL-6R (0.49, 0.30–0.76) and fibrinogen (0.52, 0.34–0.65). IL-6, CRP and fibrinogen showed significant correlations, but not with sIL-6R. Multivariate genetic analysis found that these correlations could be best explained by a common pathway model, where the common factor explained 27%, 73% and 25% of the variance of IL-6, CRP and fibrinogen, respectively. About 46% (95% CI: 21–64%) of the correlations among the three inflammatory markers could be explained by the genetic factors. After adjusting for covariates known to influence inflammation levels, heritability estimates were slightly decreased but the overall results remained similar.
Conclusions
A significant part of the variation in inflammatory marker levels is due to genetic influences. Furthermore, almost 50% of the shared variance among these biomarkers is due to a common genetic factor which likely plays a key role in the regulation of inflammation. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Genetic and environmental influences on systemic markers of inflammation in middle-aged male twins
遗传和环境因素对中年男性双胞胎炎症标志物的影响
Abstract
摘要
Objectives
The aims of this study were to determine the relative influence of genetic and environmental contributions to inflammatory biomarkers, and to what extent correlations among these markers are due to genetic or environmental factors.
目的
本研究的目的是确定遗传和环境因素对炎症标志的相对影响，以及标志物的由遗传和环境因素决定的相关联的范围。 由于牵涉到了我不熟悉的知识（统计学方面），我只能很抱歉地说战友们我尽力了，可能会有很多错误，还望战友们指正，能让我由学习的机会。 Heritability was substantial for CRP (0.61, 95% CI: 0.47–0.72) and moderate to fair for IL-6
应该是说：CRP的遗传度较高，而IL-6 ，sIL-6R 和fibrinogen的遗传度为轻到中度 不管翻译的怎么样先学习下,
lyong74 wrote:
Heritability was substantial for CRP (0.61, 95% CI: 0.47–0.72) and moderate to fair for IL-6
应该是说：CRP的遗传度较高，而IL-6 ，sIL-6R 和fibrinogen的遗传度为轻到中度
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作者:admin@医学,生命科学 2010-12-20 05:11
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