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【商业翻译】TUNEL-an efficient prognosis predictor of s
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British Journal of Cancer (2007) 96, 11011106.
doi:10.1038/sj.bjc.6603655 Published online 27 February 2007
TUNEL an efficient prognosis predictor of salivary malignancies
O Ben-Izhak1, Z Laster2, S Araidy2 and R M Nagler3
1Department of Pathology, Rambam Medical Center, Haifa, Israel
2Department of Oral and Maxillofacial Surgery, Poriya Hospital, Tiberias, Israel
3Surgery and Oral Biochemistry Laboratory, Department of Oral and Maxillofacial Surgery, Rambam Medical Center and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Biological markers are necessary for predicting prognosis of salivary malignancies and better understanding the pathogenesis of salivary cancer. We analysed terminal deoxynucleotidyl transferase (TdT)-mediated biotinylated deoxyuridine-triphosphate (dUTP)-biotin nick-end labelling (TUNEL), p53 and Ki67 expression in 66 patients with malignant salivary tumours by immonohistochemistry, and correlated the data with survival, disease-free survival, tumour grade, stage, and local and distant metastasis. TUNEL efficiently predicted poor prognosis in salivary malignancies. The 5-year (5Y) survival probability dropped significantly with the level of TUNEL staining (from 83% in negatively stained tumours to 57 and 24% in TUNEL positively stained levels 1 and 2, respectively), (P=0.042). Extensive Ki67 staining (in addition to TUNEL) reduced the 5Y-survival rate even further and addition of positively stained p53 dropped the 5Y-survival rate to 0. The correlation rates between TUNEL and Ki67 was 58% (P=0.0001), and between TUNEL and p53 it was 50% (P=0.035). Concurrently, TUNEL correlated with metastasis, extracapsular spread, grade and stage. The correlation between TUNEL, p53 and Ki67 staining and survival probabilities, and the pathological grade, stage and metastasis spread of salivary malignancies makes this a highly effective tool in patient follow-up and prognosis.
Keywords: TUNEL; prognosis; malignancies; salivary glands British Journal of Cancer (2007) 96, 11011106.
来源：《英国癌症杂志》(2007) 96, 1101-1106.
DOI:10.1038/sj.bjc.6603655 Published online 27 February 2007
TUNEL an efficient prognosis predictor of salivary malignancies
标题：TUNEL：涎腺恶性肿瘤预后的高效预测标记
作者：O Ben-Izhak1, Z Laster2, S Araidy2 and R M Nagler3
作者单位：
1、Department of Pathology, Rambam Medical Center, Haifa, Israel
1、以色列海法拉姆巴姆医疗中心病理科
2、Department of Oral and Maxillofacial Surgery, Poriya Hospital, Tiberias, Israel
以色列太巴列Poriya 医院口腔颌面外科
3、Surgery and Oral Biochemistry Laboratory, Department of Oral and Maxillofacial Surgery, Rambam Medical Center and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
3、以色列海法市特克尼奥恩技术学院、Bruce Rappaport 医院系、拉姆巴姆医疗中心、口腔颌面外科、口腔颌面外科生化实验室
Biological markers are necessary for predicting prognosis of salivary malignancies and better understanding the pathogenesis of salivary cancer. We analysed terminal deoxynucleotidyl transferase (TdT)-mediated biotinylated deoxyuridine-triphosphate (dUTP)-biotin nick-end labelling (TUNEL), p53 and Ki67 expression in 66 patients with malignant salivary tumours by immonohistochemistry, and correlated the data with survival, disease-free survival, tumour grade, stage, and local and distant metastasis.
生物学标志物对预测涎腺恶性肿瘤的预后是必需的，能更好地帮助了解涎腺癌的发病机理。 通过免疫组化方法，我们分析了66例恶性涎腺肿瘤患者的末端脱氧核苷酸转移酶(TdT)介导的生物素酰化脱氧尿苷三磷酸（dUTP）生物素原位缺口末端标记法(TUNEL)、p53 及 Ki67的表达，以及与生存期、无病生存期、肿瘤分级、分期、局部及远处转移的相互关系。
TUNEL efficiently predicted poor prognosis in salivary malignancies. The 5-year (5Y) survival probability dropped significantly with the level of TUNEL staining (from 83% in negatively stained tumours to 57 and 24% in TUNEL positively stained levels 1 and 2, respectively), (P=0.042). Extensive Ki67 staining (in addition to TUNEL) reduced the 5Y-survival rate even further and addition of positively stained p53 dropped the 5Y-survival rate to 0. The correlation rates between TUNEL and Ki67 was 58% (P=0.0001), and between TUNEL and p53 it was 50% (P=0.035). Concurrently, TUNEL correlated with metastasis, extracapsular spread, grade and stage. The correlation between TUNEL, p53 and Ki67 staining and survival probabilities, and the pathological grade, stage and metastasis spread of salivary malignancies makes this a highly effective tool in patient follow-up and prognosis.
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作者:admin@医学,生命科学 2010-11-18 17:11
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