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【bio-news】降低体温可延长小鼠寿命
Thu Nov 2, 2006 6:16pm ET
By Will Dunham
WASHINGTON (Reuters) - Lowering the body temperature of mice extended their life span by up to 20 percent, said scientists studying how to prolong life on Thursday, but they said it was impractical to do this with people.
Researchers previously found that the life span of warm-blooded animals could be lengthened by cutting calories consumed.
But the mice used in the new study, published in the journal Science, were permitted to eat as much food as they wanted while their core body temperature was lowered modestly.
"We are showing that there is a way to obtain the benefit on life span and aging that are known to be conferred by calorie restrictions without necessarily undergoing calorie restrictions," lead researcher Bruno Conti of the Scripps Research Institute in La Jolla, California said in an interview.
Scientists have known of a link between body temperature and aging in cold-blooded animals, but this was the first study to show body temperature changes impact how long warm-blooded animals live.
Animals involved in the earlier studies involving calorie restriction experienced lower body temperatures as a side effect. Researchers set out to discover whether it was the actual calorie restriction that was responsible for added longevity, with lower body temperature being incidental, or whether reduced body temperature itself was a key factor in life span.
Conti and his colleagues reduced mouse body temperatures by focusing on the hypothalamus, a brain structure that acts as the body's thermostat.
They found that mice with reduced body temperatures lived longer than those with normal temperatures. Median life span in females was extended by about 20 percent and in males by about 12 percent.
The male mice also weighed roughly 10 percent more, possibly due to the diminished energy needed to maintain a lower body temperature, researchers said.
But people wanting to live a decade or two longer are going to have to find another way, at least for now.
Conti said using the same technique in people was "technically feasible," but there is too little information on the safety of such an approach. "I'm afraid it's not too practical at this point," Conti added.
http://today.reuters.com/news/articlenews.aspx?type=scienceNews&storyID=2006-11-02T231636Z_01_N02202500_RTRUKOC_0_US-SCIENCE-LIFESPAN.xml&WTmodLoc=SciNewsHome_C1_%5bFeed%5d-7 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 降低体温可以延长小鼠寿命
WASHINGTON (Reuters) - Lowering the body temperature of mice extended their life span by up to 20 percent, said scientists studying how to prolong life on Thursday, but they said it was impractical to do this with people.
华盛顿路透社快讯：星期四，一些研究如何延长寿命的科学家们发现，降低体温可以延长老鼠20%以上的生存期。同时他们也指出这一方法并不适合于人类。 有关“限制热量可以延长寿命”的一些评论：
限制动物对热量的摄取可以延长寿命，是70 多年前的发现。目前仍是唯一被证明对大部分生物绝对有用的长寿秘诀。这种限制饮食的养生法，一般是将个体的摄食量降低到其物种普通摄食量的60%～70%。
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作者:admin@医学,生命科学 2010-11-05 17:11
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