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【medical-news】多数牛奶过敏症患儿可耐受热牛奶

Most Children With Cow's Milk Allergy Can Tolerate Heated Milk
NEW YORK (Reuters Health) Jul 21 - Seventy-five percent of children with milk allergy will tolerate extensively heated milk, according to a report in the July 15th online issue of the Journal of Allergy and Clinical Immunology.

Children with persistent milk allergy have antibodies against specific sequential epitopes, according to Dr. Anna Nowak-Wegrzyn, from Mount Sinai School of Medicine in New York, and her colleagues. Children who have outgrown their milk allergies, however, usually have milk-specific IgE antibodies directed against conformational epitopes. Because conformational epitopes can largely be destroyed through exposure to high temperatures, the researchers reasoned that children with milk allergy might tolerate milk if it were extensively heated (baked).

In the study, 100 children were given various milk challenges. First, baked muffins and waffles containing heated milk protein were given. If these were tolerated, the subject was then given unheated milk. Subjects with tolerance to heated, but not unheated, milk continued to receive heated store-bought or home-baked products containing milk for 3 months and were then reassessed.

Overall, 68 children tolerated heated milk, but not unheated milk, 23 reacted to heated milk, and 9 tolerated both heated and unheated milk, the findings show.

Compared with the other groups, the heat reactive group had larger skin prick test wheals and higher casein-specific and milk-specific IgE levels. Moreover, the symptoms seen in heated milk-reactive subjects during heated milk challenge were more severe than those observed in heated milk-tolerant subjects who reacted to unheated milk.

Relative to their baseline values, subjects who ingested heated milk for 3 months had smaller skin prick test wheals and higher casein-IgG4. By contrast, no change in other immunologic parameters, intestinal permeability, or growth were noted.
http://www.medscape.com/viewarticle/577808

"If confirmed, [the findings] should change our approach to the diagnosis and management of milk allergy," the authors conclude. "Allowing ingestion of heated milk products will dramatically improve the quality of life for the majority of subjects with milk allergy by vastly increasing the variety of food products they are able to consume."

J Allergy Clin Immunol 2008.
http://www.medscape.com/viewarticle/577808 本人已认领该文编译,48小时后若未提交译文,请其他战友自由认领。 Most Children With Cow's Milk Allergy Can Tolerate Heated Milk
多数牛奶过敏症患儿不怕热牛奶
NEW YORK (Reuters Health) Jul 21 - Seventy-five percent of children with milk allergy will tolerate extensively heated milk, according to a report in the July 15th online issue of the Journal of Allergy and Clinical Immunology.

7月15日在线出版的《过敏与临床免疫》杂志上发表的一份报告表明,有75%的牛奶过敏症患儿能够耐受热牛奶。

Children with persistent milk allergy have antibodies against specific sequential epitopes, according to Dr. Anna Nowak-Wegrzyn, from Mount Sinai School of Medicine in New York, and her colleagues. Children who have outgrown their milk allergies, however, usually have milk-specific IgE antibodies directed against conformational epitopes. Because conformational epitopes can largely be destroyed through exposure to high temperatures, the researchers reasoned that children with milk allergy might tolerate milk if it were extensively heated (baked).

持续牛奶过敏症患儿具有抑制特殊序列表位的抗体,根据来自纽约Mount Sinai医学院的Dr. Anna Nowak-Wegrzyn和她的同事。然而,患有牛奶过敏症的儿童通常具有定向抑制构象表位的特殊牛奶的IgE。这是由于暴露在高温时构象表位将极大地被破坏,研究人员推测牛奶过敏症患儿可能耐受经过充分加热(烘烤)的牛奶。

In the study, 100 children were given various milk challenges. First, baked muffins and waffles containing heated milk protein were given. If these were tolerated, the subject was then given unheated milk. Subjects with tolerance to heated, but not unheated, milk continued to receive heated store-bought or home-baked products containing milk for 3 months and were then reassessed.
在研究中,100名儿童被给予各种牛奶进行挑战。首先,给予他们含有加热过的牛奶蛋白的松饼和蛋饼。如果这些食品被接受,接下来则是给予未加热的牛奶。对加热牛奶耐受(但对未加热牛奶不耐受)的患儿连续三个月接受加热过的商店购买或自制的含有牛奶的产品,然后进行重新评估。

Overall, 68 children tolerated heated milk, but not unheated milk, 23 reacted to heated milk, and 9 tolerated both heated and unheated milk, the findings show.

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作者:admin@医学,生命科学    2010-10-17 05:11
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