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【medical-news】ACEI预防急性心肌梗死后心脏破裂
28 January 2008
MedWire News: Early ACE inhibitor therapy reduces in-hospital cardiac deaths after acute myocardial infarction (MI) largely by preventing cardiac rupture, a study suggests.
The study authors, led by Aldo Maggioni (ANMCO Research Center, Florence, Italy), note that large-scale clinical trials demonstrating the benefit of ACE inhibitors during the acute and post-MI period have scarcely reported on causes of death.
The researchers retrospectively studied data from the GISSI-3 study comparing lisinopril with no alternative medication in patients hospitalized with an acute MI.
The trial showed a trend toward lower in-hospital mortality with lisinopril versus control standard therapy (5.3% vs 5.9%, p=0.07) and significantly lower 6-week mortality (6.4% vs 7.2%, p=0.03)
For the current analysis, the researchers focused on 17,994 patients - 8950 allocated to lisinopril and 8994 to the control group - with confirmed MI and for whom complete mortality data were available, including the date and/or cause of death.
As reported in the American Heart Journal, cardiac deaths accounted for 91% of all in-hospital mortality and trended toward being less frequent among patients receiving lisinopril than those in the no-lisinopril group (4.7% vs 5.3%, odds ratio [OR]=0.88, p=0.052).
Pump failure and electromechanical dissociation/cardiac rupture were the most common causes of cardiac death.
Patients taking lisinopril had a 39% lower relative risk for death from cardiac rupture than those not taking the ACE inhibitor (0.37% vs 0.61%, OR=0.61; p=0.02). There were also trends toward reductions in mortality due to left ventricular failure and electromechanical dissociation with lisinopril, the authors report.
Further analysis showed there was also a significant reduction in early death (within 4 days of hospitalization) due to cardiac rupture with lisinopril (0.22% vs 0.47%, OR=0.49; p=0.005).
"Early administration of ACE inhibitors in unselected patients with AMI should be considered standard therapy to reduce early deaths, specifically those due to cardiac rupture," the authors conclude.
Am Heart J 2008; 155: 388-394
http://www.incirculation.net/NewsItem/ACE-inhibitor-prevents-cardiac-rupture-after-acute.aspx 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 ACE inhibitor prevents cardiac rupture after acute MI
ACEI预防急性心肌梗塞后心脏破裂
28 January 2008
2008年1月28日
MedWire News: Early ACE inhibitor therapy reduces in-hospital cardiac deaths after acute myocardial infarction (MI) largely by preventing cardiac rupture, a study suggests.
MedWire新闻：一项研究提示，及早血管紧张素转换酶抑制剂治疗可以预防心脏破裂，从而减少院内急性心肌梗塞后心源性死亡。
The study authors, led by Aldo Maggioni (ANMCO Research Center, Florence, Italy), note that large-scale clinical trials demonstrating the benefit of ACE inhibitors during the acute and post-MI period have scarcely reported on causes of death.
由Aldo Maggioni （意大利佛罗伦萨ANMCO研究中心）牵头的研究人员申明，大规模临床试验不断证实对心肌梗塞急性期及梗塞后患者血管紧张素转换酶治疗的裨益，但这些试验绝少提及死因分析。
The researchers retrospectively studied data from the GISSI-3 study comparing lisinopril with no alternative medication in patients hospitalized with an acute MI.
研究人员回顾性分析来自GISSI-3的数据，这项研究就急性心肌梗塞入院患者，比较赖诺普利治疗组与非替换标准治疗组（可能指必须标准治疗，不允许选择）疗效差异。
The trial showed a trend toward lower in-hospital mortality with lisinopril versus control standard therapy (5.3% vs 5.9%, p=0.07) and significantly lower 6-week mortality (6.4% vs 7.2%, p=0.03)
这项研究提示，赖诺普利治疗组与对照标准治疗组比较，显著减少了6周死亡率(6.4% vs 7.2%, p=0.03) ，同时有减少院内死亡率的趋势（5.3% vs 5.9%, p=0.07）。
For the current analysis, the researchers focused on 17,994 patients - 8950 allocated to lisinopril and 8994 to the control group - with confirmed MI and for whom complete mortality data were available, including the date and/or cause of death.
现今，研究者关注一项纳入17,994名患者的研究分析，－8950名患者分配到赖诺普利治疗组，8994名患者进入对照组－这些患者心肌梗塞确诊，并有死亡率数据，包括日期和/或死亡原因。
As reported in the American Heart Journal, cardiac deaths accounted for 91% of all in-hospital mortality and trended toward being less frequent among patients receiving lisinopril than those in the no-lisinopril group (4.7% vs 5.3%, odds ratio [OR]=0.88, p=0.052).
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作者:admin@医学,生命科学 2011-06-23 19:15
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