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Sexual Dysfunction? Try a Different Antidepressant 性功能障
by Leonard DeRogatis, Ph.D.
Close to 20 million Americans suffer from some form of clinical depression, and many of them have multiple episodes of depression during their lifetime.
This high prevalence of depression heightens the need for effective treatments. There are currently more than two dozen FDA-approved antidepressants on the market right now, all of which have some degree of proven efficacy.
Unfortunately, one major side effect of most antidepressant medications is sexual dysfunction, with reported rates as high as 70 percent in some studies.
This presents an extremely problematic situation, not only because of the distress and discomfort associated with sexual dysfunction, but also because evidence suggests that more than half of all patients will stop taking their antidepressants because of this side effect.
At a recent scientific meeting, I heard about a study comparing two relatively new antidepressants: Lexapro (escitalopram, one of the selective serotonin reuptake inhibitors or SSRIs) with Cymbalta (duloxetine, one of the class of drugs known as serotonin and noradrenaline reuptake inhibitors or SNRIs).
Rates of sexual dysfunction in hundreds of patients taking one of these two drugs were compared with rates observed in patients taking placebo.
To summarize a series of complex comparisons, in a head-to-head comparison Cymbalta demonstrated substantially lower levels of sexual side effects than did Lexapro. At four weeks and eight weeks of treatment, the Lexapro group demonstrated significantly higher rates of sexual dysfunction than the placebo group, whereas rates for the Cymbalta group were never significantly different than the placebo group.
If you are currently taking an antidepressant and are suffering sexual dysfunction as a result, ask your doctor whether another antidepressant that may have fewer sexual side effects might be suitable for you. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Sexual Dysfunction? Try a Different Antidepressant
性功能障碍? 换一种抗抑郁药试试
Leonard DeRogatis, Ph.D.
作者：Leonard DeRogatis博士
Close to 20 million Americans suffer from some form of clinical depression, and many of them have multiple episodes of depression during their lifetime.
接近2000万的美国人患有某种形式的临床抑郁症，其中许多人在他们的一生中经历多次抑郁症发作。
This high prevalence of depression heightens the need for effective treatments. There are currently more than two dozen FDA-approved antidepressants on the market right now, all of which have some degree of proven efficacy.
抑郁症的普遍存在使得对其进行有效治疗的需求也很多。 市场上现在有20多种经联邦食品药品监督管理局（FDA）批准的抗抑郁药，全都有不同程度的效果。
Unfortunately, one major side effect of most antidepressant medications is sexual dysfunction, with reported rates as high as 70 percent in some studies.
不幸的是，大部分抗抑郁药的主要副作用之一为性功能障碍，一些研究报告认为，发生率可高达70%。
This presents an extremely problematic situation, not only because of the distress and discomfort associated with sexual dysfunction, but also because evidence suggests that more than half of all patients will stop taking their antidepressants because of this side effect.
性功能障碍给人带来的不仅仅是烦恼和不安，甚至还有证据表明一半以上的服用抗抑郁药的患者因为这一副作用而停药，这就导致出现一种很麻烦的局面。
At a recent scientific meeting, I heard about a study comparing two relatively new antidepressants: Lexapro (escitalopram, one of the selective serotonin reuptake inhibitors or SSRIs) with Cymbalta (duloxetine, one of the class of drugs known as serotonin and noradrenaline reuptake inhibitors or SNRIs).
在最近的一次科学会议上，我听到一项有关两种较新的抗抑郁药的比较研究。 一种是Lexapro(西酞普兰，一种选择性血清素再摄入抑制剂，简称SSRI)，另一种是Cymbalta(度洛西丁，一种血清素及去甲肾上腺素再摄入抑制剂，简称SNRI)。
Rates of sexual dysfunction in hundreds of patients taking one of these two drugs were compared with rates observed in patients taking placebo.
对几百例服用这两种药物之一的患者中出现性功能障碍的比率与服用安慰剂患者的比率进行了比较。
To summarize a series of complex comparisons, in a head-to-head comparison Cymbalta demonstrated substantially lower levels of sexual side effects than did Lexapro. At four weeks and eight weeks of treatment, the Lexapro group demonstrated significantly higher rates of sexual dysfunction than the placebo group, whereas rates for the Cymbalta group were never significantly different than the placebo group.
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作者:admin@医学,生命科学 2011-04-07 18:32
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