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【bio-news】科学家报道和言语障碍相关基因
Print Submitted: 2009-8-27 17:16 Source: University of Kansas
LAWRENCE, KAN. – A new candidate gene for Specific Language Impairment has been identified by a research team directed by Mabel Rice at the University of Kansas, in collaboration with Shelley Smith, University of Nebraska Medical Center, and Javier Gayán of Neocodex, Seville, Spain. The finding, reported in the current issue of the Journal of Neurodevelopmental Disorders, was discovered by examining genes previously identified as candidate genes for reading impairments or speech sound disorders. The results point toward the likelihood of multiple genes contributing to language impairment, some of which also contribute to reading or speech impairment.
A gene on Chromosome 6 – KIAA0319 – was associated with variability in language abilities in a study of children with Specific Language Impairment (SLI) and their family members, as well as with variability in speech and reading abilities. Children with SLI who were selected for the study had no hearing loss, general intellectual deficit or autism.
Language ability involves vocabulary and grammar, whereas speech involves the accuracy of sound production. Both language and speech ability contribute to a child's ability to read. The finding that a candidate gene could influence all three abilities suggests a common pathway that could contribute to overlapping strengths or deficiencies across speech, language and reading.
According to Rice, "We don't understand the biological mechanisms yet but it's important that we have identified the first gene that could be involved across these three different dimensions of development."
Previous research has established that Chromosome 6 is among those that are linked to Speech Sounds Disorder (SSD) and Reading Disability/Dyslexia (RD). Rice said the findings are consistent with numerous reports documenting that language impairments and reading disability often co-exist.
The study involved 322 individuals, including children with SLI, their parents, siblings, and other family members. "We have come to realize that language really sets the platform for reading to emerge and to thrive," Rice added. "Without a solid language system, it's much harder to get reading going."
The study is part of a 20-year research program conducted by Rice, who is the Fred and Virginia Merrill Distinguished Professor of Advanced Studies and director of the Center for Biobehavioral Neurosciences in Communication Disorders at KU's Life Span Institute. Co-investigators on the genetics project were Shelley Smith, professor of pediatrics in the Department of Pediatrics and the Munroe Meyer Institute for Genetics and Rehabilitation at the University of Nebraska Medical Center, and Javier Gayán, Head of the Analysis Group at Neocodex, in Seville, Spain. Neocodex is a research company that specializes in genomics analysis. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Researchers report gene associated with language, speech and reading disorders
研究者报道发现语言和阅读障碍相关基因
Print Submitted: 2009-8-27 17:16 Source: University of Kansas
LAWRENCE, KAN. – A new candidate gene for Specific Language Impairment has been identified by a research team directed by Mabel Rice at the University of Kansas, in collaboration with Shelley Smith, University of Nebraska Medical Center, and Javier Gayán of Neocodex, Seville, Spain. The finding, reported in the current issue of the Journal of Neurodevelopmental Disorders, was discovered by examining genes previously identified as candidate genes for reading impairments or speech sound disorders. The results point toward the likelihood of multiple genes contributing to language impairment, some of which also contribute to reading or speech impairment.
由Kansas大学Mabel Rice领衔的研究小组最近鉴定了一个与特定语言障碍相关的新候选基因，同时参与这项研究的还有Nebraska大学医学中心的Shelley Smith和西班牙Neocodex大学的Javier Gayán。他们通过对已鉴定的一些阅读功能障碍和语言声音缺陷相关候选基因进行进一步仔细筛选，从而发现了这个新的候选基因，这项发现已经发表在当期的神经发育疾病杂志（Journal of Neurodevelopmental Disorders）上。
A gene on Chromosome 6 – KIAA0319 – was associated with variability in language abilities in a study of children with Specific Language Impairment (SLI) and their family members, as well as with variability in speech and reading abilities. Children with SLI who were selected for the study had no hearing loss, general intellectual deficit or autism.
通过对具有特定语言障碍（SLI）的儿童及其家人的研究发现，KIAA0319-----一个位于6号染色体的基因的差异性与语言、言语及阅读能力相关。参与这项研究的SLI儿童均无听力和智力及心理障碍。
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作者:admin@医学,生命科学 2010-10-05 05:11
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