主页 > 医学讨论 >
【medical-news】仅年龄问题构不成肝移植的障碍
Age alone not a barrier to liver transplantation
Mon Aug 20, 2007 5:16PM EDT
NEW YORK (Reuters Health) - The findings from a study of septuagenarians suggest that age per se should not prevent a patient from having a liver transplant.
According to a report in the Archives of Surgery, older patients often do well, provided that any accompanying risk factors are appropriately addressed.
"Biological and physiological variables may play a more important role than advanced age in predicting poor survival after liver transplantation," senior author Dr. Ronald W. Busuttil, from the University of California at Los Angeles, and colleagues state.
The team compared the outcome of 62 transplant recipients age 70 years or older with those of 864 recipients in their 50s. All of the patients were first-time recipients and underwent transplantation between 1988 and 2005.
No significant differences in survival were noted between the two age groups. For the older group, the 1-, 5-, and 10-year survival rates were 73 percent, 47 percent, and 40 percent, respectively.
The corresponding survival rates for the younger group were 79 percent, 65 percent, and 45 percent.
After more extensive analysis, the researchers identified some patient factors that significantly predicted death. These included the need for hospitalization before the surgery, hepatitis C infection, and alcoholic cirrhosis.
Conversely, being 70 years of age or older not a significant predictor of death.
Measures that assess a patient's age based on his physical condition, rather than his chronological age, as well as estimates of the risk of complications "should be used in the evaluation process of elderly transplant candidates."
"Chronologic age by itself is not a sole predictor of outcome," the authors conclude.
SOURCE: Archives of Surgery, August 2007. Age alone not a barrier to liver transplantation
Mon Aug 20, 2007 5:16PM EDT
年龄不是肝脏移植的障碍
2007年八月20日，星期一 17：16编
NEW YORK (Reuters Health) - The findings from a study of septuagenarians suggest that age per se should not prevent a patient from having a liver transplant.
纽约（路透社健康频道）一项研究表明年龄不应该成为肝移植的障碍。
According to a report in the Archives of Surgery, older patients often do well, provided that any accompanying risk factors are appropriately addressed.
根据《外科学档案》的一篇报道，如果能够充分重视危险因素的话，老年人也能够进行肝移植。
"Biological and physiological variables may play a more important role than advanced age in predicting poor survival after liver transplantation," senior author Dr. Ronald W. Busuttil, from the University of California at Los Angeles, and colleagues state.
“作为预测肝脏移植预后的指标，生物学和生理学指标要比高龄更有意义”，来自于加利福尼亚大学的Ronald W Bustttil和他的同事这样说。
The team compared the outcome of 62 transplant recipients age 70 years or older with those of 864 recipients in their 50s. All of the patients were first-time recipients and underwent transplantation between 1988 and 2005.
他们比较了70岁以上的肝脏移植患者62名和864名50多岁的肝脏移植患者的预后情况。所有的患者均是第一次接受移植，移植的时间都再1988年到2005年之间。
No significant differences in survival were noted between the two age groups. For the older group, the 1-, 5-, and 10-year survival rates were 73 percent, 47 percent, and 40 percent, respectively.
结果没有发现两组之间的生存期具有显著性差异。对于年长组，1年、5年、10年的生存率分别是73％、47％和40％，
The corresponding survival rates for the younger group were 79 percent, 65 percent, and 45 percent.
对应组（50多岁组）的生存率分别为：79％、65％和45％。
After more extensive analysis, the researchers identified some patient factors that significantly predicted death. These included the need for hospitalization before the surgery, hepatitis C infection, and alcoholic cirrhosis.
通过进一步的分析，研究人员发现患者的一些指标与死亡明显相关，这包括了移植前是否需要住院、丙型肝炎感染和酒精性肝硬化。
Conversely, being 70 years of age or older not a significant predictor of death.
与之相反的是，年龄为70岁或者更大的年龄并不预示患者死亡。
Measures that assess a patient's age based on his physical condition, rather than his chronological age, as well as estimates of the risk of complications "should be used in the evaluation process of elderly transplant candidates." "Chronologic age by itself is not a sole predictor of outcome," the authors conclude.
依据生理技能为基础所调整的年龄，而不是十足年龄，也能够可以移植并发症的风险，“这一点应该被用来评估老年患者，十足年龄不应该成为判断预后的独立指标。”作者这样总结。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-02-16 17:12
医学,生命科学网