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【medical-news】超生理剂量的睾酮对老年男性记忆
NEW YORK (Reuters Health) Dec 13 - The results of a small crossover study suggest that supraphysiological testosterone levels may have detrimental effects on memory and brain function in elderly men, investigators at the University of Illinois at Chicago report.
Multiple lines of evidence link low testosterone levels to cognitive decline and dementia in aging men, Dr. Pauline M. Maki and her associates note in the November Journal of Clinical Endocrinology and Metabolism. Some studies have suggested beneficial effects of testosterone enanthate treatment and high serum testosterone, but the overall findings have been mixed.
The researchers conducted a double-blind, placebo-controlled crossover study with 15 healthy, eugonadal men ages 66 to 86, with no evidence of cognitive dysfunction. Intramuscular injections of testosterone enanthate 200 mg and sesame oil placebo were administered every other week for 90 days, with a 90-day washout between treatments. Neuropsychological testing and positron emission tomography were conducted 7 to 10 days after the final injection in each phase.
Total testosterone levels more than doubled after active treatment, the team reports.
But contrary to their expectations, the testosterone treatment was associated with declines of "medium effect size" in short-term verbal memory score (p < .05) and a nonsignificant decrease in composite verbal memory score (p = .09), as measured with the California Verbal Learning Test.
"Neuroimaging data provided insights into the neural basis for this decline in function," Dr. Maki and her associates state. "With testosterone treatment, relative activity decreased in the medial temporal lobe..., a pattern observed in preclinical Alzheimer's disease in a region that is critical for episodic memory."
Although this trial suggests that high doses of testosterone enanthate over long intervals may be harmful, Dr. Maki's group believes that "the results do not rule out potential benefits with other regimens, cognitive tests, or populations."
J Clin Endocrinol Metab 2007;92:4107-4114.
http://www.medscape.com/viewarticle/567445 粗粗翻译了一下，居然还是有点难的，有些还真的补怎么明白希望大家指正。（有颜色的部分，大家看看有没有译错啊）
High Testosterone Enanthate Dose May Impair Memory in Older Men
大剂量庚酸睾酮可能损伤老年男性的记忆
NEW YORK (Reuters Health) Dec 13 - The results of a small crossover study suggest that supraphysiological testosterone levels may have detrimental effects on memory and brain function in elderly men, investigators at the University of Illinois at Chicago report.
纽约（路透社健康部）12月13日－一项小型的病例交叉设计的结果提示：超过生理剂量的睾酮水平可能对老年男性的记忆和大脑有不利的作用。这项研究结果由芝加哥的伊利诺大学的研究人员公布。
Multiple lines of evidence link low testosterone levels to cognitive decline and dementia in aging men, Dr. Pauline M. Maki and her associates note in the November Journal of Clinical Endocrinology and Metabolism. Some studies have suggested beneficial effects of testosterone enanthate treatment and high serum testosterone, but the overall findings have been mixed. 编译（615个中文）
大剂量庚酸睾酮可能损伤老年男性的记忆
纽约（路透社健康部）12月13日－一项小型的、由芝加哥的伊利诺大学的研究人员公布的病例交叉设计的结果提示：超过生理剂量的睾酮水平可能对老年男性的记忆和大脑有不利的影响。Pauline M. Maki医生和他的注意到了发表在11月刊登在《临床内分泌和代谢病杂志》上的“关于多重证据将的睾酮水平和老年男性的认知的下降和痴呆联系在一起”的报道。一些研究结果提示，庚酸睾酮治疗和血清高睾酮水平的益处，但是所有结果都是被混在了一起。
于是研究者们，设计了一个双盲的，安慰剂对照的有15名健康的，年龄在66岁到86岁间的老年男性参加的试验。参加试验的老年男性没有认知减退的证据。每隔1周，肌注庚酸睾酮 200mg天或以麻油为成分的安慰剂，连续90天，在两个治疗之间有90天的洗脱期。神经心理学测试和正电子发射断层摄影检查在每个时期结束后10天进行。
“总睾酮的水平比直接疗法后的睾酮水平高2倍多。”研究者报告说。
但是和他们期望的不同，睾酮治疗对短期言语记忆评分的下降有影响(p < .05)，对混合语言记忆评分没有显著的影响(p = .09)。（这两种评分都是用加州言语学习测验测定的。）
“神经影像的数据提供了功能下降的神经学基础的证据。” Maki医生和他的同事们声称，“中颞叶的相对活性降低，这与在早老性痴呆前期患者这个区域观察到的现象一致，这个区域对情节记忆而言是至关重要的。”
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作者:admin@医学,生命科学 2011-08-14 05:14
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