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【drug-news】低剂量阿司匹林改善中老年认知功能
BMJ 2008;337:a1198
Objective To determine the effects of low dose aspirin on cognitive function in middle aged to elderly men and women at moderately increased cardiovascular risk.
Design Randomised double blind placebo controlled trial.
Setting Central Scotland.
Participants 3350 men and women aged over 50 participating in the aspirin for asymptomatic atherosclerosis trial.
Intervention Low dose aspirin (100 mg daily) or placebo for five years.
Main outcome measures Tests of memory, executive function, non-verbal reasoning, mental flexibility, and information processing five years after randomisation, with scores used to create a summary cognitive score (general factor).
Results At baseline, mean vocabulary scores (an indicator of previous cognitive ability) were similar in the aspirin (30.9, SD 4.7) and placebo (31.1, SD 4.7) groups. In the primary intention to treat analysis, there was no significant difference at follow-up between the groups in the proportion achieving over the median general factor cognitive score (32.7% and 34.8% respectively, odds ratio 0.91, 95% confidence interval 0.79 to 1.05, P=0.20) or in mean scores on the individual cognitive tests. There were also no significant differences in change in cognitive ability over the five years in a subset of 504 who underwent detailed cognitive testing at baseline.
Conclusion Low dose aspirin does not affect cognitive function in middle aged to elderly people at increased cardiovascular risk. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 欢迎校对～
Low dose aspirin and cognitive function in middle aged to elderly adults: randomised controlled trial
低剂量阿司匹林改善中老年认知功能的随机对照研究
BMJ 2008;337:a1198
Objective To determine the effects of low dose aspirin on cognitive function in middle aged to elderly men and women at moderately increased cardiovascular risk.
目的：为了确定低剂量阿司匹林对心血管风险轻微增加的中老年人认知功能的影响。
Design Randomised double blind placebo controlled trial.
试验设计：随机双盲安慰剂对照试验
Setting Central Scotland.
地点：苏格兰中部。
Participants 3350 men and women aged over 50 participating in the aspirin for asymptomatic atherosclerosis trial.
受试者：参与阿司匹林治疗无症状性动脉硬化试验的3350名50岁以上老年人。
Intervention Low dose aspirin (100 mg daily) or placebo for five years.
治疗方案：低剂量阿司匹林或安慰剂（100mg/d），治疗五年。
Main outcome measures Tests of memory, executive function, non-verbal reasoning, mental flexibility, and information processing five years after randomisation, with scores used to create a summary cognitive score (general factor).
主要评价结果：五年的随机对照试验后，测定受试者的记忆力、执行功能、非言语推理、心理应激能力及信息处理能力，用这些评分计算出总认知得分（综合因子）。
Results At baseline, mean vocabulary scores (an indicator of previous cognitive ability) were similar in the aspirin (30.9, SD 4.7) and placebo (31.1, SD 4.7) groups. In the primary intention to treat analysis, there was no significant difference at follow-up between the groups in the proportion achieving over the median general factor cognitive score (32.7% and 34.8% respectively, odds ratio 0.91, 95% confidence interval 0.79 to 1.05, P=0.20) or in mean scores on the individual cognitive tests. There were also no significant differences in change in cognitive ability over the five years in a subset of 504 who underwent detailed cognitive testing at baseline.
结果：开始时，阿司匹林组（30.9, SD 4.7）和安慰剂组(31.1, SD 4.7)的词汇量表平均得分（表明以前的认知能力）类似。随访中，两组的主要评价指标无显著差别，包括：高于综合认知因子评分中位数的人数比例（分别为32.7% ，34.8% , 优势比0.91, 95%可信区间0.79-1.05, P=0.20）及各受试者认知测试平均得分。其中504名患者在试验开始时接受了细致地认知测试，结果显示，经过五年治疗，两组的认知能力改善也无显著差别。
Conclusion Low dose aspirin does not affect cognitive function in middle aged to elderly people at increased cardiovascular risk.
结论：对心血管风险增大的中老年患者而言，低剂量阿司匹林不会改善其认知功能。 编译：
为了确定低剂量阿司匹林对心血管风险轻微增加的对中老年人认知功能的影响，研究人员在苏格兰中部进行了一项随机双盲安慰剂对照试验，对参加阿司匹林治疗无症状动脉硬化试验的3350名50岁以上老年人进行了研究。
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作者:admin@医学,生命科学 2010-09-26 05:11
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