主页 > 医学动态 >
【科普】记忆丧失前大脑结构变化数年
记忆丧失前大脑结构变化数年
ST. PAUL, Minn ，People who develop dementia or Alzheimer's disease experience brain structure changes years before any signs of memory loss begin, according to a study published in the April 17, 2007, issue of Neurology the scientific journal of the American Academy of Neurology. Researchers say these findings may help identify people at risk of developing mild cognitive impairment (MCI), which leads to Alzheimer's disease.
ST. PAUL, Minn，根据2007年4月17号美国神经研究院科学期刊——神经期刊的发表研究，痴呆或阿尔茨海默患者在有记忆丧失迹象之前已经历了大脑结构变化数年。研究者说这些发现可以帮助识别存在轻度认识障碍（MCI）风险的人们，MIC会导致阿尔茨海默病。
Researchers performed brain scans and cognitive tests on 136 people over the age of 65 who were considered cognitively normal at the beginning of the five-year study. Participants were then followed annually with neurologic examination and extensive mental status testing. By the end of the study, 23 people had developed MCI, and nine of the 23 went on to be diagnosed with Alzheimer's disease. The brain scans of the 23 people with memory loss were then compared to the 113 people who remained cognitively normal.
研究者对65岁以上的136人进行脑部扫描和认知测试，这些人在5年研究初期被认为是认知正常。参加者每年都被跟踪进行神经检查和广泛的心理状态测试。
Compared to the group that didn't develop memory problems, the 23 people who developed MCI or Alzheimer's disease had less gray matter in key memory processing areas of their brains even at the beginning of the study when they were cognitively normal.
与没有记忆问题的小组比较，患有MCI或阿尔茨海默症 的23人，在他们被认为认知正常的研究初期，有较少的灰质在他们脑部的关键记忆加工区域。
"We found that changes in brain structure are present in clinically normal people an average of four years before MCI diagnosis," said study author Charles D. Smith, MD, with the University of Kentucky Medical Center in Lexington and member of the American Academy of Neurology. "We knew that people with MCI or Alzheimer's disease had less brain volume, but before now we didn't know if these brain structure changes existed, and to what degree, before memory loss begins."
“我们发现在MCI诊断之前临床正常的人群中脑部结构变化出现平均4年”研究作者Charles D. Smith说, 他是列克星敦的肯塔基大学医学中心硕士和美国神经研究院的会员. “我们知道MCI 或阿尔茨海默症患者有较少的脑容积，但在这之前，我们不明白这些脑部结构变化是否存在，在记忆丧失开始之前达到什么程度？
In addition, the study found those people destined to develop MCI had lower cognitive test scores at the beginning of the study compared to the group that didn't develop memory problems, even though these scores were still within normal range.
此外研究发现与没有记忆问题的小组比较，那些注定会得MCI的人在研究初期有更低的认知测试分数，尽管这些分数仍在正常范围内。
"These findings of structural changes in cognitively normal people before memory loss begins aren't surprising given Alzheimer's disease may be present for many years before symptoms of the disease begin to appear," said Smith.
Smith说“记忆丧失之前，在认知正常的人中结构变化的发现并不令人吃惊，因为阿尔茨海默病在出现症状之前可能存在很多年”。 记忆丧失前大脑结构变化数年
ST. PAUL, Minn，根据2007年4月17号美国神经研究院科学期刊——神经期刊的发表研究，痴呆或阿尔茨海默患者在有记忆丧失迹象之前已经历了大脑结构变化数年。研究者说这些发现可以帮助识别存在轻度认识障碍（MCI）风险的人们，MIC会导致阿尔茨海默病。
研究者对65岁以上的136人进行脑部扫描和认知测试，这些人在5年研究初期被认为是认知正常。参加者每年都被跟踪进行神经检查和广泛的心理状态测试。
与没有记忆问题的小组比较，患有MCI或阿尔茨海默症 的23人，在他们被认为认知正常的研究初期，有较少的灰质在他们脑部的关键记忆加工区域。
“我们发现在MCI诊断之前临床正常的人群中脑部结构变化出现平均4年”研究作者Charles D. Smith说, 他是列克星敦的肯塔基大学医学中心硕士和美国神经研究院的会员. “我们知道MCI 或阿尔茨海默症患者有较少的脑容积，但在这之前，我们不明白这些脑部结构变化是否存在，在记忆丧失开始之前达到什么程度？
此外研究发现与没有记忆问题的小组比较，那些注定会得MCI的人在研究初期有更低的认知测试分数，尽管这些分数仍在正常范围内。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-04-07 18:32
医学,生命科学网