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【medical-news】人造心脏组织为百万患者带来希望
The home-grown heart tissue that brings hope to millions
by FIONA MACRAE - More by this author »
Last updated at 00:38am on 3rd April 2007
British scientists led by Sir Magdi Yacoub have grown part of a human heart in a breakthrough that offers hope for millions of cardiac patients.
Such artificially-grown tissue could be used to replace damaged heart valves within three years.
In the future, larger sections of tissue could repair heart attack damage, prolonging and improving the quality of life of tens of thousands in the UK alone.
In less than a decade, it may be possible to grow an entire human heart - cutting the need for transplants.
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Sir Magdi and his team generated the heart tissue from stem cells found in the bone marrow. ture, the technique is likely to be seen as more ethically sound because the stem cells were taken from marrow rather than from an embryo in the first few days of life.
Their achievement comes after Israeli researchers said last month that they had succeeded in growing a tiny beating 'heart in a dish' from embryonic stem cells.
The muscle, which contained more than one type of cell, was threaded with minute blood vessels and closely resembled the complex tissue of the human heart.
While the heart tissue created in British labs has a simpler struc-The harvesting of such stem cells typically results in the death of the embryo, and some to argue it is wrong to sacrifice human life to further medical research.
Sir Magdi, a professor of cardiac surgery and world-renowned heart surgeon, said the possibility of growing an entire heart was "an ambitious project but not impossible".
He added: "If you wanted me to guess, I'd say ten years."
"But experience has shown that progress that is happening nowadays make it possible to achieve milestones in a shorter time. I wouldn't be surprised if it was sometime sooner than we think."
Stem cells are blank cells with the ability to turn into different tissue types, offering much promise as a 'repair kit' for the body.
Sir Magdi's team, from Imperial College London and Harefield Hospital, West London, coaxed them into turning into heart cells. Placed on a biodegradable framework, the cells grew and fused together to form tiny discs of heart valve tissue, just three centimetres wide.
Transplants into animals planned for later this year will show how well the lab-grown tissue fares in the body and could pave the way for human trials.
Patients, including children, suffering from valve defects are likely to be the first to benefit, with whole heart valves generated from stem cells in use in three to five years.
Each year in the UK around 10,000 children and adults have valves damaged by disease and ageing replaced.
Adults with defective valves are usually given artificial replacements, while children are given valves from human donors. However, neither solution is perfect.
Those given artificial valves have to take drugs for life to prevent blood clots forming, while donor valves are in short supply and tend to deteriorate over time.
Other experts welcomed the research, which was part-funded by the British Heart Foundation and will be published in the journal Philosophical Transactions of the Royal Society in August. They cautioned, however, that the technique is still in its infancy. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 http://www.dailymail.co.uk/pages/live/articles/health/healthmain.html?in_article_id=446083&in_page_id=1774
The home-grown heart tissue that brings hope to millions
国产人造心脏组织为百万患者带来希望
by FIONA MACRAE -
Last updated at 00:38am on 3rd April 2007
发表日期：2007－4－3
British scientists led by Sir Magdi Yacoub have grown part of a human heart in a breakthrough that offers hope for millions of cardiac patients.
Such artificially-grown tissue could be used to replace damaged heart valves within three years.
由Magdi Yacoub爵士领衔的英国科学家最近在心脏组织制造方面有了巨大的突破，从而为数百万心脏病患者带来希望。
In the future, larger sections of tissue could repair heart attack damage, prolonging and improving the quality of life of tens of thousands in the UK alone.
在不久的未来，较大的组织块可以用来修复心脏病发作所导致的损伤，仅仅在英国就可以延长和改善数以万计的人的生命质量。
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作者:admin@医学,生命科学 2011-08-13 05:11
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