【Blood】中枢的霍奇金淋巴瘤
Central nervous system (CNS) involvement by Hodgkin lymphoma (HL) is rare. As a result, there is limited guidance for clinicians on how to manage these patients. Detailed information was collected on 16 patients, the largest number to date, with meningeal or parenchymal CNS-HL confirmed by histopathology (15) or CSF (1). Eight patients presented with CNS-HL at diagnosis, 2 of whom had isolated CNS disease, while 8 patients developed CNS-HL at relapse. Patients received a range of treatments including surgery or radiation alone, radiation with chemotherapy, or chemotherapy alone. Median overall survival for all 16 patients was 60.9 months from first diagnosis of HL (systemic or CNS) and 43.8 months from diagnosis of CNS-HL. Although a majority of patients have died, long-term survival is possible in patients who achieve a complete response to treatment, particularly those who present with CNS involvement or involvement of the CNS is the sole site of relapsed disease.
本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领
Central nervous system (CNS) involvement by Hodgkin lymphoma (HL) is rare. As a result, there is limited guidance for clinicians on how to manage these patients. 霍奇金淋巴瘤的中枢神经系统累计较少见。于是针对这些患者的临床指南很少。Detailed information was collected on 16 patients, the largest number to date, with meningeal or parenchymal CNS-HL confirmed by histopathology (15) or CSF (1). 该研究收集了16名患者的详细信息，这是目前为止最大数目的研究，都得到了病理或脑脊液证实的脑膜或脑实质中枢神经淋巴瘤。Eight patients presented with CNS-HL at diagnosis, 2 of whom had isolated CNS disease, while 8 patients developed CNS-HL at relapse. 8名患者初次诊断为中枢神经系统淋巴瘤，他们中的2名患者患者独立中枢神经系统淋巴瘤，其他8名患者属于复发患者。Patients received a range of treatments including surgery or radiation alone, radiation with chemotherapy, or chemotherapy alone.患者时接受了一系列治疗包括单独手术或单独放疗，放化结合、单独化疗。 Median overall survival for all 16 patients was 60.9 months from first diagnosis of HL (systemic or CNS) and 43.8 months from diagnosis of CNS-HL. 16名患者的中位生存时间为60.9个月（从第一次诊断系统性或中枢性淋巴瘤开始）和43.8个月（从诊断中枢神经系统淋巴瘤算起）。Although a majority of patients have died, long-term survival is possible in patients who achieve a complete response to treatment, particularly those who present with CNS involvement or involvement of the CNS is the sole site of relapsed disease.虽然大部分患者已经去世，但长期生存率无法在取得完全缓解的患者中估计，特别是那些中枢累及或仅以单独中枢复发的患者。
霍奇金淋巴瘤的中枢神经系统累计较少见。于是针对这些患者的临床指南很少。该研究收集了16名患者的详细信息，这是目前为止最大数目的研究，都得到了病理或脑脊液证实的脑膜或脑实质中枢神经淋巴瘤。8名患者初次诊断为中枢神经系统淋巴瘤，他们中的2名患者患者独立中枢神经系统淋巴瘤，其他8名患者属于复发患者。患者时接受了一系列治疗包括单独手术或单独放疗，放化结合、单独化疗。 16名患者的中位生存时间为60.9个月（从第一次诊断系统性或中枢性淋巴瘤开始）和43.8个月（从诊断中枢神经系统淋巴瘤算起）。虽然大部分患者已经去世，但长期生存率无法在取得完全缓解的患者中估计，特别是那些中枢累及或仅以单独中枢复发的患者。
[标签:content1][标签:content2]
阅读本文的人还阅读：
【社会人文】如果不给予
【文摘发布】帕金森病治
【drug-news】英国报道显示
【bio-news】应用干细胞技
【medical-news】改进电刺激
作者:admin@医学,生命科学 2011-08-14 05:11
医学,生命科学网
