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【文摘发布】胰岛移植失败后的高致敏风险
Author：P. M. Campbell, P. A. Senior, A. Salam，et al.
Source：American Journal of Transplantation 7 (10), 2311–2317.
Abstract：Human Leukocyte Antigen (HLA) antibodies posttransplant have been associated with an increased risk of early graft failure in kidney transplants. Whether this also applies to islet transplantation is not clear. To achieve insulin independence after islet transplants multiple donor infusions may be required. Hence, islet transplant recipients are at risk of sensitization after transplantation. Islet transplant recipients were screened for HLA antibodies posttransplant by flow-based methods. A total of 98 patients were studied. Twenty-nine patients (31%) developed de novo donor specific antibodies (DSA) posttransplant. Twenty-three patients developed DSA while on immunosuppression (IS). Among recipients who have discontinued IS, 10/14 (71%) are broadly sensitized with panel reactive antibody (PRA) ≥50%. The risk of becoming broadly sensitized after transplant was 11/69 (16%) if the recipient was unsensitized prior to transplant. The majority of these antibodies have persisted over time. Appearance of HLA antibodies posttransplant is concerning, and the incidence rises abruptly in subjects weaned completely from IS. This may negatively impact the ability of these individuals to undergo further islet, pancreas or kidney transplantation and should be discussed upfront during evaluation of candidates for islet transplantation. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title：High Risk of Sensitization After Failed Islet Transplantation
题目：胰岛移植失败后的高致敏风险
Author：P. M. Campbell, P. A. Senior, A. Salam，et al.
作者：P. M. Campbell, P. A. Senior, A. Salam，et al.
Source：American Journal of Transplantation 7 (10), 2311–2317.
出处：《美国移植杂志》7 (10), 2311–2317.
Abstract：Human Leukocyte Antigen (HLA) antibodies posttransplant have been associated with an increased risk of early graft failure in kidney transplants. Whether this also applies to islet transplantation is not clear.
摘要：人白细胞抗原(HLA)抗体与肾移植中的早期移植肾衰竭的风险增高有关。胰岛移植时风险是否增高尚不清楚。
To achieve insulin independence after islet transplants multiple donor infusions may be required. Hence, islet transplant recipients are at risk of sensitization after transplantation. Islet transplant recipients were screened for HLA antibodies posttransplant by flow-based
doctormy wrote:
Abstract：Human Leukocyte Antigen (HLA) antibodies posttransplant have been associated with an increased risk of early graft failure in kidney transplants. Whether this also applies to islet transplantation is not clear.
摘要：人白细胞抗原(HLA)抗体与肾移植中的早期移植肾衰竭的风险增高有关。胰岛移植时风险是否增高尚不清楚 谢谢神农草版主的指正，Whether this also applies to islet transplantation is not clear.这句话当时漏掉了，不好意思，呵呵！
现已对原文稿做了必要的修改！ hao ya [标签:content1][标签:content2]阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-08-13 17:11
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