主页 > 生命科学 >
【medical-news】小儿肾移植的长期效果
Main Category: Pediatrics News
Article Date: 11 Jan 2007 - 0:00 PST
UroToday.com- Rees, et al from the Great Ormond Street Hospital for Children and the Royal Free Hospital in London report their experience of pediatric renal transplantation from the beginning of their program. They retrospectively reviewed patient and transplant survival and influencing factors in the 300 children transplanted between 1973-2000.
The group found that 300 children have received a total of 354 transplantations. Fifty-six were living related donations. The median age at transplantation was 10.3 years. Forty-four percent had congenital structural abnormalities of the urinary tract. Forty-six children required a second and 8 required a third transplantation. The overall patients survival at 5, 10 and 20 years was 97, 94 and 72% respectively. In the overall cohort, the donor type did not affect mortality, nor did age at transplantation. However, those transplanted before 5 years of age had a significantly shorter post-transplant survival time.
Transplant survival after the first transplant for deceased and living-related donors was 66 and 87% at 5 years, 51 and 54% at 10 years, and 36% at 20 years (deceased-donor transplants only.) Although the overall transplant survival was inferior in children transplanted before 2 years of age, in the most recent cohort between 1990-2000, age did not affect the outcome. They performed a multiple regression analysis and found that the only predictor of transplant survival was the era of transplantation. The median final height was within the normal range for males and females. Seven patients required growth hormone after transplantation.
The group concluded that the outlook for successful transplantation is improving, especially in the last decade where age did not affect the success of transplantation. The group stated that survival of living related donor transplants is superior to cadaveric transplants for the first 5 years. They feel that they can predict that a 10 year old child receiving a transplant in 2000 also on cyclosporin-based immunosuppression can expect a transplant half-life of approximately 13.1 years from a living-related donor and one of 10.8 tears from cadaveric transplantation. These are very promising results which will require further investigation and warrant future updating.
Rees L, Shroff R, Hutchinson C, Fernando ON, Trompeter RS.
Nephron Clinical Practice 105(2): 68-76, 2007.
http://www.medicalnewstoday.com/medicalnews.php?newsid=60541 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Long-Term Outcome Of Pediatric Renal Transplantation: Follow-Up Of 300 Children From 1973 To 2000
小儿肾移植的长期效果: 从1973年到2000年追踪调查了300名儿童.
Main Category: Pediatrics News
类别:儿科新闻
Article Date: 11 Jan 2007 - 0:00 PST
文章日期:2007.1.11
UroToday.com- Rees, et al from the Great Ormond Street Hospital for Children and the Royal Free Hospital in London report their experience of pediatric renal transplantation from the beginning of their program. They retrospectively reviewed patient and transplant survival and influencing factors in the 300 children transplanted between 1973-2000.
UroToday.com-来自英国伦敦大奥曼德街医院和皇家自由医院儿科的rees等人报道了他们进行的小儿肾移植方面的经验.他们对在1973-2000年间接受移植的300名儿童进行研究,分别对他们的健康状况,移植存活率及相关影响因素进行了回顾调查.
The group found that 300 children have received a total of 354 transplantations. Fifty-six were living related donations. The median age at transplantation was 10.3 years. Forty-four percent had congenital structural abnormalities of the urinary tract. Forty-six children required a second and 8 required a third transplantation. The overall patients survival at 5, 10 and 20 years was 97, 94 and 72% respectively. In the overall cohort, the donor type did not affect mortality, nor did age at transplantation. However, those transplanted before 5 years of age had a significantly shorter post-transplant survival time.
他们调查发现这300名儿童接受了约354次移植手术.其中有56%是亲属间活体移植.接受移植手术的儿童平均年龄为10.3岁.44%的病人有先天性泌尿道结构异常.46%儿童须进行二次移植,而8%的则需要三次移植.患者移植后5年,10年,20年后存活率分之别为97%,94%和72%.在所有的年龄组中,供体类型并不影响死亡率,接受移植时的年龄也是如此.然而, 那些在5岁前接受移植的患者存活期明显变短.
Transplant survival after the first transplant for deceased and living-related donors was 66 and 87% at 5 years, 51 and 54% at 10 years, and 36% at 20 years (deceased-donor transplants only.) Although the overall transplant survival was inferior in children transplanted before 2 years of age, in the most recent cohort between 1990-2000, age did not affect the outcome. They performed a multiple regression analysis and found that the only predictor of transplant survival was the era of transplantation. The median final height was within the normal range for males and females. Seven patients required growth hormone after transplantation.
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-03-10 17:11
医学,生命科学网