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【药学】关节炎药物治疗紫外损伤皮肤效果奇特
Cincinnati, OH, June 29, 2006 ?For many women, accumulated sun exposure has already permanently damaged their skin cells, causing them to overproduce pigment that shows up as unsightly dark splotches and uneven skin tone over time. But new research indicates that glucosamine - a compound best known for treating arthritis ?can actually help stop the formation of new age spots, and help fade existing ones.
"These findings on glucosamine may impact the way dermatologists treat UV-related skin damage in the future. Right now we have prescription and surgical options, which some people aren't willing to try," says Alexa Kimball, M.D., assistant professor of dermatology, Harvard Medical School and lead researcher on one of the studies testing glucosamine. "It's exciting to see this level of research being done on topical cosmetic applications of glucosamine, and the promising results."
An International Consensus on Glucosamine Skin Benefits In early 2006, a group of leading dermatologists from around the world and Procter & Gamble Beauty scientists convened in Rome to review and discuss the glucosamine data. The panel determined that n-acetyl glucosamine, a more stable form of glucosamine, reduced the amount of melanin in skin cells, meaning there was less excess pigment in the skin to cause age spots. Additionally, the panel concluded that a formulation of n-acetyl glucosamine and niacinamide, a vitamin B derivative, significantly reduced the amount and appearance of hyperpigmentation, age spots and uneven melanin distribution. Researchers paired n-acetyl glucosamine with niacinamide because they knew that niacinamide had similar effects on slowing down pigment production and hypothesized that the two might work better together.
The panel reviewed data from three studies involving the n-acetyl glucosamine /niacinamide formulation. Tissue studies showed a reduction in melanin and an increase in collagen ?a key structural protein in skin. Three double-blinded placebo- controlled clinical studies involving more than 200 subjects, including a study supervised by Dr. Kimball, showed improvement in hyperpigmentation and skin tone and a decrease in the size of age spots. The research is set to be presented in July at the "Academy '06" meeting of the American Academy of Dermatology (AAD), and was first presented at the AAD annual meeting in March 2006.
Skin Biology Gives Researchers Clues for Developing New Treatments The interest in glucosamine as a possible treatment comes in part from what scientists already know happens on a cellular level when skin is exposed to UV radiation. Chronic UV exposure can damage melanocytes, cells in the skin responsible for producing melanin, in a variety of different ways. Often, this damage can lead to a loss of cellular control, and the production of chemicals that allow the cells to keep producing more and more melanin ?which eventually leads to age spots and uneven discoloration. Additionally, as skin ages, cell turnover slows down and melanin "dust" ?microscopic particles of melanin ?can become trapped in the upper layers of skin, resulting in a duller appearance.
Researchers are familiar with these processes and that has helped them focus on substances - such as n-acetyl glucosamine - that are known to interrupt the UV-triggered chemical signals that turn on melanin production. Skin care products that utilize signal-blocking ingredients currently exist in the marketplace, but products with n-acetyl glucosamine/niacinamide - which block melanin at two different points in the pigment producing process - are among the newest and most studied.
"Pigmentation is an appearance issue that strikes an emotional chord for women, and even though we're constantly telling our patients about the importance of UV-protection, once the damage is done, we need to be able to provide them with ways to help," says Dr. Kimball. "The level of research and validation on topical cosmetic application of glucosamine will help it stand apart from other ingredients when it comes to improving tone and treating hyperpigmentation." 科学发现在关节炎治疗中为紫外线损害的皮肤新的修复
Cincinnati, OH, June 29, 2006。对很多妇女而言，累积的日光照射已经永久性损害她们的皮肤细胞，导致这些细胞过多产生色素显露难看的黑色斑点和随着时间过去不均匀的肤色。但是新的研究表明葡萄糖胺——一种以治疗关节炎而闻名的化合物，能够切实的帮助停止新的老年斑形成，和帮助消退存在的斑点。
“这些有关葡萄糖胺的发现也许在未来影响皮肤科医师治疗紫外线有关的皮肤损伤的方法。立刻，我们就可以开处方和手术选择，其中一些患者不愿意去尝试，”Alexa Kimball说, 医学博士，皮肤医学助理副教授，哈佛医学院和某一项试验葡萄糖胺研究的首席研究员。令人兴奋的是看到葡萄糖胺在局部美容应用已经达到的研究水平，及有希望的结果。
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作者:admin@医学,生命科学 2011-02-23 05:14
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