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【medical-news】海藻中可以提取出确定疗效的抗癌
http://www.news-medical.net/?id=40822
Duke University chemists have patented an efficient technique for synthesizing a marine algae extract in sufficient quantities to now test its ability to inhibit the growth of cancerous cells while leaving normal cells unaffected.
The researchers also deduced that this molecule -- called largazole -- acts on cells through the same chemical mechanism as other anti-cancer compounds on the market or in clinical trials. "It's a very exciting molecule," said Jiyong Hong, a Duke assistant chemistry professor.
Hong's graduate student, Yongcheng Ying, will describe the work in an Aug. 20 talk in Philadelphia during the 236th national meeting of the American Chemical Society. It has also been described in a May 29 report in the Journal of the American Chemical Society (JACS).
Hendrik Luesch, a natural product chemist at the University of Florida who led the group that discovered largazole, was a corresponding author of the May JACS report along with Hong. Luesch's team first extracted and identified largazole from a marine blue-green algae collected at Key Largo, Fla.
Guided by evidence of therapeutic benefits from extracts of a related algae, the Florida group demonstrated that largazole could impede breast cancer cell growth better than the anti-tumor drug Taxol without causing Taxol-like side effects on normal breast tissue.
But Luesch's group "isolated just one milligram, a very tiny amount, from natural sources that were very difficult to grow," Hong said. "We needed to develop a concise and efficient synthetic route to make enough largazole for animal studies."
Winning a race with several other groups, the Duke team devised a method to produce gram-sized quantities -- about 1,000 times more -- by identifying three key building blocks in largazole's ring-shaped molecular architecture.
The scientists were then able to use commercially available chemicals to make largazole in eight steps, netting what Hong called a "very, very efficient" 20 percent yield.
"My lab's next task was finding the origin of lagarzole's biological activity," Hong said. The molecule appeared to initiate some signaling cascades that could affect inappropriately proliferating cells but not normal ones.
In the process of sleuthing this question, Hong said his group accidentally discovered that largazole was structurally similar to another molecule called FK228. FK228 is known to inhibit histone deacytelases (HDACs), enzymes regulating genetic activity that can foment cancerous cell growth.
The Duke team confirmed that, like FK228, largazole also suppressed HDACs. Another HDAC suppressor, marketed as Zolinza, has now been approved for the treatment of T-cell lymphoma, Hong said. Others, including FK228, are undergoing clinical trials as anti-cancer drugs.
Hong's group is now doing follow-up research aimed at changing largazole's structure to increase its effects on cell growth. "It could be a very good drug candidate for the treatment of various cancers," he said.
http://www.duke.edu 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Scientists synthesize promising anti-cancer product from marine algae
科学家利用海藻合成有前途的抗癌药物
http://www.news-medical.net/?id=40822
Duke University chemists have patented an efficient technique for synthesizing a marine algae extract in sufficient quantities to now test its ability to inhibit the growth of cancerous cells while leaving normal cells unaffected.
杜克大学的化学家具有一项有效率的专利技术，合成一种海藻提取物，目前测试到它在足量时能够抑制癌细胞的生长，而对正常细胞没有影响。
The researchers also deduced that this molecule -- called largazole -- acts on cells through the same chemical mechanism as other anti-cancer compounds on the market or in clinical trials. "It's a very exciting molecule," said Jiyong Hong, a Duke assistant chemistry professor.
研究人员同时推断这种被称为largazole的分子，通过与市场上或临床试验中的其他抗癌化合物相同的化学机理作用于细胞。“这是一个非常令人兴奋的分子，”杜克大学的助理化学教授Jiyong Hong说。
Hong's graduate student, Yongcheng Ying, will describe the work in an Aug. 20 talk in Philadelphia during the 236th national meeting of the American Chemical Society. It has also been described in a May 29 report in the Journal of the American Chemical Society (JACS).
Hong的研究生Yongcheng Ying将于8月20日在费城召开的第236届美国化学协会(JACS)全国会议期间阐述这一研究工作。同时也将在5月29日的JACS期刊发表报告。
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作者:admin@医学,生命科学 2011-01-05 05:14
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