主页 > 生命科学 >
【medical-news】母亲孕期感染增加子女患白血病的
By Megan Rauscher
NEW YORK (Reuters Health) Jan 12 - An episode of influenza or pneumonia, or sexually transmitted disease, around the time of pregnancy significantly increases the risk of childhood leukemia among offspring, results of a case-control study indicate.
These observations "suggest that maternal infection might contribute to the develop of childhood leukemia, which has been postulated to have an infectious origin," Dr. Marilyn L. Kwan, from the Division of Research at Kaiser Permanente in Oakland, California told Reuters Health.
As reported in the January 1st issue of the American Journal of Epidemiology, she and her colleagues studied 365 children diagnosed with childhood leukemia and 460 matched controls. Data on maternal illnesses and drug use from before pregnancy through breastfeeding were obtained by interview with the biologic mother.
The investigators found that maternal history of influenza/pneumonia occurring in the period from 3 months prior to pregnancy through the end of breastfeeding was associated with a statistically significant increased risk of childhood leukemia (OR = 1.74) and acute lymphoblastic leukemia (OR = 1.89) in the offspring.
Maternal history of sexually transmitted disease (Chlamydia, genital herpes, and HPV) in the period around pregnancy was associated with an odds ratio of 6.33 for childhood leukemia and 4.85 for acute lymphoblastic leukemia (ALL), according to the report.
Maternal use of iron supplements was significantly associated with decreased risks of both childhood leukemia and ALL in offspring (OR = 0.70 and 0.67, respectively).
"Overall, these results emphasize the importance of maintaining good health while pregnant, which has always been an overarching policy promoted by clinicians in order to have a smooth pregnancy and healthy baby," Dr. Kwan concluded.
Am J Epidemiol 2007;165:27-35.
http://www.medscape.com/viewarticle/550702 Maternal Infection May Raise Risk of Childhood Leukemia
母亲孕期感染增加子女患白血病的风险
By Megan Rauscher
NEW YORK (Reuters Health) Jan 12 - An episode of influenza or pneumonia, or sexually transmitted disease, around the time of pregnancy significantly increases the risk of childhood leukemia among offspring, results of a case-control study indicate.
纽约（路透社卫生专栏）1月12 日——一项病历对照研究结果表明，母亲孕期发生流行感冒、肺炎或性传播疾病显著增加子女患儿童期白血病的风险。
These observations "suggest that maternal infection might contribute to the develop of childhood leukemia, which has been postulated to have an infectious origin," Dr. Marilyn L. Kwan, from the Division of Research at Kaiser Permanente in Oakland, California told Reuters Health.
加利福尼亚奥克兰Kaiser Permanente的研究部门的Marilyn L. Kwan博士告诉路透社健康专栏， 这些观察结果“提出母体感染可能促成儿童期白血病的发生，母体感染假定有感染源。”
As reported in the January 1st issue of the American Journal of Epidemiology, she and her colleagues studied 365 children diagnosed with childhood leukemia and 460 matched controls. Data on maternal illnesses and drug use from before pregnancy through breastfeeding were obtained by interview with the biologic mother.
如一月的第一期美国传染病杂志的报告，Marilyn L. Kwan博士和她的同事研究了365例诊断为儿童白血病的儿童和460例配对对照儿童。怀孕前到母乳喂养期母亲患病和用药数据通过和亲生母亲会谈获得。
The investigators found that maternal history of influenza/pneumonia occurring in the period from 3 months prior to pregnancy through the end of breastfeeding was associated with a statistically significant increased risk of childhood leukemia (OR = 1.74) and acute lymphoblastic leukemia (OR = 1.89) in the offspring.
研究者发现母孕期前三个月到母乳喂养结束母亲患流行性感冒/肺炎病史在统计学上和下一代儿童期白血病(OR = 1.74)及急性淋巴系统白血病(OR = 1.89) 风险增高显著相关。
Maternal history of sexually transmitted disease (Chlamydia, genital herpes, and HPV) in the period around pregnancy was associated with an odds ratio of 6.33 for childhood leukemia and 4.85 for acute lymphoblastic leukemia (ALL), according to the report.
据报告，母亲怀孕期性传播疾病病史(衣原体、生殖器疱疹、人乳头(状)瘤病毒)和儿童期白血病的优势比6.33及急性淋巴系统白血病(ALL) 优势比4.85相关。
Maternal use of iron supplements was significantly associated with decreased risks of both childhood leukemia and ALL in offspring (OR = 0.70 and 0.67, respectively).
母体铁的补充和下一代儿童期白血病及ALL风险减少显著相关(各自为：OR = 0.70 和0.67)。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-03-09 17:11
医学,生命科学网