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【medical-news】心梗后抑郁短期有害 长期死亡风险
5 March 2008
MedWire News: Depression during hospitalization for a myocardial infarction (MI) does not predict a higher risk for death in the long term, researchers have found.
Roy Ziegelstein, from the National Institutes of Health in Bethesda, Maryland, USA, and colleagues report that having any type of depression during hospitalization did not significantly predict mortality at 8 years.
The results come after an earlier report from the same cohort linked depression at hospitalization with increased mortality 4 months later.
The prospective observational study included 284 patients hospitalized for an MI.
Patients had a mean age of 65 years; 43% were women; 67% had hypertension; and 36% and diabetes mellitus.
Depression was assessed by structured interview using the Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition, and depressive symptoms using the Beck Depression Inventory.
Any depression, defined as major depression, dysthymia or a Beck Depression Inventory score of 10 or more, was identified in 76 (27%) patients.
Almost half (48%) of the patients had died by the 8-year follow-up point, and this was not significantly associated with depression at hospitalization in either univariate (hazard ratio [HR]=1.25) or multivariate (HR=0.76) analyses.
Summarizing their findings, the researchers write in the American Journal of Cardiology: "Depression after MI was associated with increased short-term mortality, but its relation with mortality over time appeared to wane, at least in a group of older patients who had multiple comorbidities."
They speculate: "This may occur because of the specific characteristics of the patient population in this study, compared with those of previous studies."
Am J Cardiol 2008; 101: 602-606
http://www.incirculation.net/NewsItem/Depression-after-MI-does-not-warn-of-longterm-mort.aspx 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Depression after MI 'does not warn of long-term mortality'
MedWire News: Depression during hospitalization for a myocardial infarction (MI) does not predict a higher risk for death in the long term, researchers have found.
MedWire 新闻：研究发现，入院治疗心肌梗死（MI）期间的抑郁并不预示着长时间有较高的死亡危险。
Roy Ziegelstein, from the National Institutes of Health in Bethesda, Maryland, USA, and colleagues report that having any type of depression during hospitalization did not significantly predict mortality at 8 years.
来自位于马里兰州贝塞斯达的国立卫生研究院（NIH）的Roy Ziegelstein和他的同事报道，住院期间的任何一种抑郁症在8年内都没有明显地预示着死亡。
The results come after an earlier report from the same cohort linked depression at hospitalization with increased mortality 4 months later.
同样是这群人在早期报道中指出住院期间的抑郁和死亡率增加有关，而在4个月后又公布了该结果。
The prospective observational study included 284 patients hospitalized for an MI.
前瞻性观察研究包括284例入院治疗MI的病人。
Patients had a mean age of 65 years; 43% were women; 67% had hypertension; and 36% and diabetes mellitus.
病人平均年龄65岁，43%是妇女，67%有高血压，36%是糖尿病。
Depression was assessed by structured interview using the Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition, and depressive symptoms using the Beck Depression Inventory.
参照美国精神病诊断和统计手册（修订第3版），抑郁症通过结构式访谈进行评价，使用Beck抑郁问卷评估抑郁的程度。
Any depression, defined as major depression, dysthymia or a Beck Depression Inventory score of 10 or more, was identified in 76 (27%) patients.
有76人被诊断为抑郁症包括定义的严重抑郁，中度抑郁或Beck问卷中不低于10分的抑郁。
Almost half (48%) of the patients had died by the 8-year follow-up point, and this was not significantly associated with depression at hospitalization in either univariate (hazard ratio [HR]=1.25) or multivariate (HR=0.76) analyses.
几乎一半（48%）的病人在8年随访点时业已去世，无论是用单因素分析（HR=1.25）还是多因素分析（HR=0.76），结果均显示这和住院期间的抑郁症并没有明显关联。
Summarizing their findings, the researchers write in the American Journal of Cardiology: "Depression after MI was associated with increased short-term mortality, but its relation with mortality over time appeared to wane, at least in a group of older patients who had multiple comorbidities."
综合研究结果，研究者在美国心脏病杂志上撰文：MI后的抑郁会增加短期的死亡率，但随着时间的延长，这一关系会日益减弱，至少在一群患有并存疾病的老年人中证实了这一点。
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作者:admin@医学,生命科学 2011-02-18 17:14
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