主页 > 生命科学 >
【medical-news】低血压可防止1型糖尿病肾病
NEWYORK (Reuters Health) Jan 08 - Low blood pressure levels, even below the accepted normal range, apparently protect against kidney disease in adults with type 1 diabetes, according to a study in the January issue of Hypertension.
"Recent recommendations have placed lower target blood pressures (<130/80 mm Hg) for subjects with diabetes than for the general population," first author Dr. Anoop Shankar from the National University of Singapore told Reuters Health. "However, these recommendations are predominantly based on studies in the general population and subjects with relatively older onset type 2 diabetes."
In younger-onset type 1 diabetes, "where hyperglycemia has been shown to have an important role in the development of vascular complications, it is uncertain whether blood pressure lowering per se has a significant protective effect against renal disease, independent of near-normal glycemic control," Dr. Shankar noted.
Dr. Shankar and colleagues from the University of Wisconsin, Madison, examined the relationship between decreasing categories of systolic and diastolic BP and the occurrence of two kidney-related conditions -- proteinuria and reduced glomerular filtration rate.
They analyzed data from 604 subjects, 232 of whom developed proteinuria over a 16-year period, and from 158 of 547 subjects who developed an estimated glomerular filtration rate of < 60 mL/min/1.73 meters-squared, in a population-based cohort of adult type 1 diabetics from Wisconsin.
"We observed that overall, over 16 years, decreasing blood pressure categories, both systolic and diastolic, had lower likelihood of developing kidney disease-related outcomes," Dr. Shankar reported. "These associations were independent of glycemic control and several putative confounding factors."
The maximum protective effect was seen at systolic BP < 120 mm Hg and diastolic BP < 70 mm Hg. These BP levels "seemed to be protectively associated with approximately 50% of these kidney disease-related outcomes at the population level," the investigators report.
Moreover, lower systolic and diastolic BP predicted regression of proteinuria over 16 years in individuals with proteinuria at baseline.
In an editorial, Dr. Matthew R. Weir of the University of Maryland, Baltimore writes: "Given the burden of kidney and cardiovascular disease associated with type 1 diabetes, interventional trials are desirable to expand on these interesting and important observations."
Hypertension 2007;49:13-14,48-54.
http://www.medscape.com/viewarticle/550460 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Low Blood Pressure May Protect Against Renal Disease in Type 1 Diabetes
题目：低血压可防止I型糖尿病肾病
NEWYORK (Reuters Health) Jan 08 - Low blood pressure levels, even below the accepted normal range, apparently protect against kidney disease in adults with type 1 diabetes, according to a study in the January issue of Hypertension.
来自1月8日纽约（路透社健康频道）的消息：据《高血压》杂志1月份文章的报道，成年人的低血压（甚至低于公认标准范围）可防止I型糖尿病肾病的发生。
"Recent recommendations have placed lower target blood pressures (<130/80 mm Hg) for subjects with diabetes than for the general population," first author Dr. Anoop Shankar from the National University of Singapore told Reuters Health. "However, these recommendations are predominantly based on studies in the general population and subjects with relatively older onset type 2 diabetes."
来自新加坡国立大学的本文第一作者Anoop Shankar博士说，“近年来建议糖尿病患者要比正常人群具有更低的血压(<130/80 mm Hg)，但是这些建议是依据正常人群和相对发病年岁大的II型糖尿病人的研究结果。
In younger-onset type 1 diabetes, "where hyperglycemia has been shown to have an important role in the development of vascular complications, it is uncertain whether blood pressure lowering per se has a significant protective effect against renal disease, independent of near-normal glycemic control," Dr. Shankar noted.
高血糖症是青年发病的I型糖尿病患者产生血管并发症的主要原因，还未确定降低血压在本质上对肾病有显著的保护作用，并且不依赖于接近正常的血糖控制。”
Dr. Shankar and colleagues from the University of Wisconsin, Madison, examined the relationship between decreasing categories of systolic and diastolic BP and the occurrence of two kidney-related conditions -- proteinuria and reduced glomerular filtration rate.
Shankar 博士和来自曼迪逊维斯康星州大学的同事们检测了心脏收缩和舒张时血压的降低和两种与肾病相关的蛋白尿和肾小球滤过率降低等指标之间的关系。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-03-09 17:11
医学,生命科学网