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【drug-news】看混合药物如何致命！
Published: Tuesday, 29-Jul-2008
A large-scale study of home medication consumption has highlighted the danger of mixing drugs.
The study by sociologists at the University of California, San Diego says expecting patients to monitor their own medications can be fatal, as the death of actor Heath Ledger who died from an accidental prescription-drug overdose at age 28, illustrates.
In a study which examined almost 50 million U.S. death certificates from 1983 to 2004, the researchers focused on the 200,000 deaths from medication errors and found a huge increase in fatal domestic medication errors involving alcohol and/or street drugs.
They say the dramatic increase in fatal medication errors is linked to a shift in the location of medication consumption from clinical to domestic settings and people increasingly take their medications at home, away from hospitals and clinics.
Lead author Dr. David P. Phillips, says they wanted to know how many of these fatal errors happen at home, how many involved alcohol and/or street drugs and whether the numbers were increasing.
The team found that deaths at home from combining medications with alcohol and/or street drugs skyrocketed by 3,196 percent, while non-domestic fatal errors which did not involve alcohol or street drugs, showed the smallest increase of just 5 percent.
Domestic medication fatalities not involving alcohol or street drugs increased by 564 percent and non-domestic medication fatalities involving alcohol and/or street drugs - increased by 555 percent.
The researchers say domestic fatal medication errors, combined with alcohol and/or street drugs, have become an increasingly important health problem.
Dr. Phillips says more research on medication errors is called for as well as changes in policy and clinical practice.
The study is published in the July 28 issue of the Archives of Internal Medicine.
http://www.news-medical.net/?id=40317 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 。 How mixing medications can be fatal
看混合药物如何致命！ 到底什么药呢? 有点不得其解阿 给些具体的内容。 给些具体的内容。 我曾查过文献，有人统计过，当然不是中国，每年全球因用药问题死亡的人数是几十万。是药三分毒是正确的。 治疗哮喘的混合药物同样可以致命 <断臂山>男主角Heath Ledger希斯莱杰于1月22日在公寓中突然死亡,年仅28岁，初步认为是服药過量
感觉上这篇文章强调并不单是MIX，而是Domestic, Domestic Fatal Medication Errors，
http://archinte.ama-assn.org/cgi/content/abstract/168/14/1561
A Steep Increase in Domestic Fatal Medication Errors With Use of Alcohol and/or Street Drugs
David P. Phillips, PhD; Gwendolyn E. C. Barker, BA; Megan M. Eguchi
Arch Intern Med. 2008;168(14):1561-1566.
Background Increasingly, medications are consumed outside of clinical settings, with relatively little professional oversight. Despite this trend, previous studies of medication errors have focused on clinical settings.
Methods We examined all US death certificates from January 1, 1983, to December 31, 2004 (N = 49 586 156), particularly those with fatal medication errors (FMEs) (n = 224 355). We examined trends in 4 types of FMEs that vary according to the relative importance of alcohol/street drugs and the relative likelihood of professional oversight in the consumption of medications.
Results The overall FME death rate increased by 360.5% (1983-2004). This increase far exceeds the increase in death rates from adverse effects of medications (33.2%) or from alcohol and/or street drugs (40.9%). The increase in FMEs varies markedly by type. Type 1 (domestic FMEs combined with alcohol and/or street drugs) shows the largest increase (3196%). In contrast, type 4 (nondomestic FMEs not involving alcohol and/or street drugs) shows the smallest increase (5%). Types 2 and 3 show intermediate increases. Type 2 (domestic FMEs not involving alcohol and/or street drugs) increased by 564%. Type 3 (nondomestic FMEs combined with alcohol and/or street drugs) increased by 555%. Thus, domestic FMEs combined with alcohol and/or street drugs have become an increasingly important health problem compared with other FMEs.
Conclusions These findings suggest that a shift in the location of medication consumption from clinical to domestic settings is linked to a steep increase in FMEs. It may now be possible to reduce FMEs by focusing not only on clinical settings but also on domestic settings.
译得很好，学习一下，小小问题讨论一下：
the researchers focused on the 200,000 deaths from medication errors and found a huge increase in fatal domestic medication errors involving alcohol and/or street drugs.
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作者:admin@医学,生命科学 2011-06-16 17:14
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