主页 > 医药生命 >
【文摘发布】本期ERJ：日本的结节病流行病学
Epidemiology of sarcoidosis in Japan
T. Morimoto1, A. Azuma1, S. Abe1, J. Usuki1, S. Kudoh1, K. Sugisaki2, M. Oritsu3 and T. Nukiwa4
Keywords: Epidemiology, incidence, Japan, sarcoidosis, sex
The present study was designed to identify recent clinical phenotypes using the National Epidemiological Survey and to compare findings with those of previous surveys in Japan.
Pathologically confirmed sarcoidosis cases newly diagnosed in 2004 were eligible for the present study. Disease parameters were recorded and compared.
A total of 1,027 patients were enrolled from a cluster encompassing 79.4% of the entire Japanese population. The study participants consisted of 364 males and 663 females, providing an average incidence rate of 1.01 per 100,000 inhabitants (0.73 for males and 1.28 for females). The age-specific incidence rate displayed a biphasic pattern in the whole patient population and in the females. The male incidence rates peaked in the 20–34-yr-old group. A second peak for 50–60-yr-old females showed a higher incidence than the first younger peak. Patients with abnormalities in eyes, skin and cardiac laboratory findings accounted for 54.8, 35.4 and 23.0% of cases, respectively. The female/male incidence ratio was increased, and the frequency of eye and skin involvement and cardiac abnormality was higher than in previous surveys conducted in Japan.
In conclusion, the data obtained in the present study differ from those of other countries and showed changes in sarcoidosis clinical phenotypes compared with previous studies in Japan. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领. Eur Respir J 2008; 31:372-379
Epidemiology of sarcoidosis in Japan
日本的结节病流行病学
T. Morimoto1, A. Azuma1, S. Abe1, J. Usuki1, S. Kudoh1, K. Sugisaki2, M. Oritsu3 and T. Nukiwa4
Keywords: Epidemiology, incidence, Japan, sarcoidosis, sex
关键词：流行病学，发病率，日本，结节病，性别
The present study was designed to identify recent clinical phenotypes using the National Epidemiological Survey and to compare findings with those of previous surveys in Japan.
此研究目的是用于统一日本目前的临床表型，通过国家流行病调查，以及与过去的调查比较来实现的。
Pathologically confirmed sarcoidosis cases newly diagnosed in 2004 were eligible for the present study. Disease parameters were recorded and compared.
入选患者：在2004年中病理诊断明确的新结节病患者。疾病数据记录并比较。
A total of 1,027 patients were enrolled from a cluster encompassing 79.4% of the entire Japanese population. The study participants consisted of 364 males and 663 females, providing an average incidence rate of 1.01 per 100,000 inhabitants (0.73 for males and 1.28 for females). The age-specific incidence rate displayed a biphasic pattern in the whole patient population and in the females. The male incidence rates peaked in the 20–34-yr-old group. A second peak for 50–60-yr-old females showed a higher incidence than the first younger peak. Patients with abnormalities in eyes, skin and cardiac laboratory findings accounted for 54.8, 35.4 and 23.0% of cases, respectively. The female/male incidence ratio was increased, and the frequency of eye and skin involvement and cardiac abnormality was higher than in previous surveys conducted in Japan.
入选患者总数为1027例，是从日本人口总数的79.4%的人当中选出的。此研究由364例男性和663例女性组成，平均发病率为1.01/100，000人口（男性为0.73，女性为1.28）.龄别发病率在全部病人总数和女性中呈现为双向型。男性的发病率高峰在20~34岁，第二个高峰为50~60岁的女性，比前个年轻高峰的发病率明显增高。眼睛，皮肤和心脏的实验室检查异常的患者分别占有 54.8%, 35.4 %and 23.0%。女性与男性发病率的比值增高，眼睛和皮肤侵犯，心脏异常与日本以往的调查研究结果相比，发生率增高。
In conclusion, the data obtained in the present study differ from those of other countries and showed changes in sarcoidosis clinical phenotypes compared with previous studies in Japan.
结论：目前研究的数据与其他国家的研究结果不同，结果并且显示，与以往的研究相比结节病的临床表型发生了改变。
编译后：
最近，在日本进行了一大型结节病的流行病学调查，通过国家流行病调查，以及与过去的调查研究结果比较来实现的，目的是用来统一目前的结节病的临床表型。
入选者为2004年病理诊断的新结节病患者。
此研究对象，男性364例和，性663例，共1027例，是从日本总人口数的79.4%当中选出的，平均发病率为1.01/100，000人口（男性为0.73，女性为1.28）。全部病人总数和女性的龄别发病率呈现双向型，男性的发病率高峰在20~34岁，第二个高峰为50~60岁的女性，比第一个年轻高峰的发病率高。眼睛，皮肤和心脏的实验室检查异常的患者分别占有 54.8%, 35.4 %and 23.0%。女性与男性发病率的比值增高，与日本以往的调查研究结果相比，眼睛和皮肤侵犯，心脏异常的发生率增高。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-06-11 05:14
医学,生命科学网