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伴有或不伴有肾小球足细胞消失的蛋白尿
http://jasn.asnjournals.org/cgi/content/abstract/17/9/2383?maxtoshow=&HITS=&hits=&RESULTFORMAT=1&andorexacttitle=and&fulltext=Goodpastures+syndrome&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&fdate=9/1/2006&resourcetype=HWCIT
原文标题和摘要：
Proteinuria with and without Renal Glomerular Podocyte Effacement
Abstract：
Renal biopsies of patients with proteinuria and kidney disease most often are associated with podocyte foot process effacement. For several decades, nephrologists have wondered whether proteinuria is a result of podocyte foot process effacement or the cause of it. In the past few years, the author’s laboratory has addressed this issue using different mouse models of proteinuria. Although in most cases, podocyte effacement is associated with proteinuria and glomerular disease, in three different mouse models, it was demonstrated that proteinuria can be observed without podocyte foot process effacement. The first model is generated by injection of antibodies to vascular endothelial growth factor or soluble vascular endothelial growth factor receptor 1. The second model is a mouse with deletion of type IV collagenα3chain in the glomerular basement membrane. The third model was generated by genetic deletion of a slit diaphragm protein known as nephrin. Collectively, these experiments and the supporting evidence from several human studies demonstrate that severe defects in either the glomerular basement membrane or the glomerular endothelium can lead to proteinuria without foot process effacement. 我的翻译
Proteinuria with and without Renal Glomerular Podocyte Effacement
标题：伴有或不伴有肾小球足细胞消失的蛋白尿
摘要：
Renal biopsies of patients with proteinuria and kidney disease most often are associated with podocyte foot process effacement.
蛋白尿和肾病的患者的肾活检结果，绝大多数常会发现有足细胞足突消失。
For several decades, nephrologists have wondered whether proteinuria is a result of podocyte foot process effacement or the cause of it.
几十年来，肾科医生对蛋白尿到底是足细胞足突消失的结果还是起因充满了好奇。
In the past few years, the author’s laboratory has addressed this issue using different mouse models of proteinuria.
过去的几年里，笔者所在的实验室从事于利用不同的鼠模型来研究这一问题。
Although in most cases, podocyte effacement is associated with proteinuria and glomerular disease, in three different mouse models, it was demonstrated that proteinuria can be observed without podocyte foot process effacement.
尽管在大多数的例子里，足细胞消失是与蛋白尿和肾小球疾病相关的；但在3种不同的鼠模型中发现，在不伴有足细胞消失的情况下，蛋白尿也可以被检测到。
The first model is generated by injection of antibodies to vascular endothelial growth factor or soluble vascular endothelial growth factor receptor 1.
第1个模型是通过注射了血管内皮生长因子的抗体，或者可溶性的血管内皮生长因子受体1，从而获得的。
The second model is a mouse with deletion of type IV collagen 3 chain in the glomerular basement membrane.
第2个模型是通过删除肾小球基底膜IV型胶原α3链而获得的。
The third model was generated by genetic deletion of a slit diaphragm protein known as nephrin.
第3个模型是通过删除一种裂孔隔膜蛋白nephrin的基因而获得的。
Collectively, these experiments and the supporting evidence from several human studies demonstrate that severe defects in either the glomerular basement membrane or the glomerular endothelium can lead to proteinuria without foot process effacement.
这些实验和一些来自人体研究的支持证据一致证明，肾小球基底膜或肾小球内皮的损伤，可以导致不伴足细胞足突消失的蛋白尿。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-03-06 17:22
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