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【medical-news】女性是否应该通过服用阿司匹林来
Wall Street Journal Examines Whether Women Should Take Aspirin To Prevent Heart Disease
Article Date: 10 Apr 2007 - 6:00 PDT
The Wall Street Journal on Tuesday examined whether women should take aspirin daily to prevent heart disease. According to the Journal, the risks and benefits of daily aspirin use are "far less clear" for women than for men. Researchers from Harvard University last week said that women participating in the Nurses Health Study who regularly took aspirin decreased their risk of heart attack by 38% and their risk for cancer by 12%. In addition, among the 80,000 participants, those who took aspirin regularly were 25% less likely to die during the study period, the Journal reports. However, an earlier Women's Health Initiative study of 40,000 women found that regular aspirin use made no difference in heart attack risk among women ages 45 and older. The conflicting data could be explained in part because the nurses study observed women's health habits, while the WHI assigned women to take either aspirin therapy or a placebo, according to the Journal. Although some women "might be tempted" to immediately begin aspirin therapy, it is not a "risk-free drug," the Journal reports. Aspirin use increases the risk for gastrointestinal bleeding by 70% -- or three additional gastrointestinal bleeding cases per 1,000 patients over five years -- and hemorrhagic stroke by 40%, or one additional hemorrhagic stroke per 1,000 patients over five years. Most experts say that healthy women under age 65 will not benefit from aspirin therapy. American Heart Association guidelines say that healthy women older than age 65 should consider taking one baby aspirin daily (Parker-Pope, Wall Street Journal, 4/3).
"Reprinted with permission from http://www.kaisernetwork.org. You can view the entire Kaiser Daily Health Policy Report, search the archives, or sign up for email delivery at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Daily Health Policy Report is published for kaisernetwork.org, a free service of The Henry J. Kaiser Family Foundation . © 2005 Advisory Board Company and Kaiser Family Foundation. All rights reserved. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 The Wall Street Journal on Tuesday examined whether women should take aspirin daily to prevent heart disease.
来自周二的华尔街杂志的内容――妇女是否应该每天服用阿司匹林以预防心脏病的发生。
According to the Journal, the risks and benefits of daily aspirin use are "far less clear" for women than for men. Researchers from Harvard University last week said that women participating in the Nurses Health Study who regularly took aspirin decreased their risk of heart attack by 38% and their risk for cancer by 12%. In addition, among the 80,000 participants, those who took aspirin regularly were 25% less likely to die during the study period, the Journal reports.
该杂志认为，在每日服用阿司匹林是否获益的问题上，女士能否获益的问题远没有男士能够获益的证据充分。上周的来自哈佛大学的研究表明：护士健康研究的参与者中，每日规律服用阿司匹林可以减少38％的心脏病发作，减少12％的肿瘤发生。此外，该研究中的80000名参与者中，服用阿司匹林组在研究期间的死亡率降低了25％。
However, an earlier Women's Health Initiative study of 40,000 women found that regular aspirin use made no difference in heart attack risk among women ages 45 and older.
然而，另一项较早的约有40000人参加的 WHI研究则发现，45岁以上（含45岁）的妇女服用阿司匹林与对照组在心脏病发病率上无明显差别。
The conflicting data could be explained in part because the nurses study observed women's health habits, while the WHI assigned women to take either aspirin therapy or a placebo, according to the Journal.
造成结果差异的原因，该杂志解释一部分可能因为护士健康研究是对参与者的健康习惯进行观察，而WHI研究则让参加者服用阿司匹林或者安慰剂进行研究。
Although some women "might be tempted" to immediately begin aspirin therapy, it is not a "risk-free drug," the Journal reports. Aspirin use increases the risk for gastrointestinal bleeding by 70% -- or three additional gastrointestinal bleeding cases per 1,000 patients over five years -- and hemorrhagic stroke by 40%, or one additional hemorrhagic stroke per 1,000 patients over five years.
杂志称：尽管有部分妇女会因此而立即服用阿司匹林，但是实际上它并非无风险药物。使用阿司匹林可增加70％的胃肠道出血或者每1000名病人中出现3例胃肠道出血，还可以增加40％的出血性卒中发生或者每年1/1000的出血性脑卒中。
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作者:admin@医学,生命科学 2011-03-05 05:11
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