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【Stroke】狂饮成为卒中的独立危险因素
Increased Stroke Risk Is Related to a Binge Drinking Habit
Laura Sundell MD*; Veikko Salomaa MD, PhD; Erkki Vartiainen MD, PhD; Kari Poikolainen MD, PhD; and Tiina Laatikainen MD, PhD
From the Department of Health Promotion and Chronic Disease Prevention (L.S., V.S., E.V., T.L.), National Public Health Institute (KTL), Helsinki; the University of Kuopio (L.S.), Kuopio; and the Finnish Foundation for Alcohol Studies and Department of Mental Health and Alcohol Research (K.P.), National Public Health Institute (KTL), Helsinki, Finland.
* To whom correspondence should be addressed. E-mail: laura.sundell@ktl.fi.
Background and Purpose—Heavy alcohol consumption increases the risk for all strokes, whereas moderate regular alcohol consumption is associated with a lower risk for ischemic stroke. The purpose of this study was to evaluate the effect of different drinking patterns on stroke risk, independent of average alcohol intake.
Methods—A prospective cohort study of 15 965 Finnish men and women age 25 to 64 years who participated in a national risk factor survey and had no history of stroke at baseline were followed up for a 10-year period. The first stroke event during follow-up served as the outcome of interest (N=249 strokes). A binge drinking pattern was defined as consuming 6 or more drinks of the same alcoholic beverage in men or 4 or more drinks in women in 1 session. Cox proportional-hazards models were adjusted for average alcohol consumption, age, sex, hypertension, smoking, diabetes, body mass index, educational status, study area, study year, and history of myocardial infarction.
Results—Binge drinking was an independent risk factor for total and ischemic strokes. Compared with non–binge drinkers, the hazard ratio for total strokes among binge drinkers was 1.85 (95% CI, 1.35 to 2.54) after adjusting for average alcohol consumption, age, and sex; the association was diluted after adjustment for other risk factors. Compared with non–binge drinkers, the risk for ischemic stroke was 1.99 (95% CI, 1.39 to 2.87) among binge drinkers; the association remained statistically significant after adjustment for potential confounders.
Conclusions—This study found that a pattern of binge drinking is an independent risk factor for all strokes and ischemic stroke. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 狂饮成为卒中独立危险因素
Increased Stroke Risk Is Related to a Binge Drinking Habit 狂饮成为卒中独立危险因素[标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-03-05 17:11
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