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【medical-news】百忧解对儿童弱视有效
LONDON (Reuters) - Prozac, the popular antidepressant, might also be an effective treatment for adults with a "lazy eye", according to new research.
A team of Italian and Finnish scientists said on Thursday that the medicine helped correct the eyesight of rats whose vision had been impaired in early development and it could well do the same for humans.
The medicine appears to work by returning neurons in the adult brain to a more "plastic" state normally only seen in youth. This allows the visual perception system to develop its proper connections between the eye and the brain.
The discovery could also help explain exactly how antidepressants help regulate mood in depressed patients, by suggesting brain plasticity is a key part of the process.
Prozac was initially introduced by U.S. drugmaker Eli Lilly and Co in 1987 and belongs to a class of compounds called selective serotonin reuptake inhibitors (SSRIs). It is now off patent and widely available generically as fluoxetine.
Jose Fernando Maya Vetencourt from Scuola Normale Superiore in Pisa and colleagues intend to go on to study the drug's curative properties on human eyesight, though definitive clinical trial plans have yet to be developed.
"It will take a couple of years, maybe more," he told Reuters.
Amblyopia, commonly known as "lazy eye", is the most frequent cause of visual impairment in childhood and affects 2 to 3 percent of children, according to the U.S. National Eye Institute.
Unless it is successfully treated, it usually persists into adulthood. Treatment involves making the child use the weaker eye, either by applying an eye patch or by putting drops in the stronger eye to temporarily blur the vision.
There is no proven treatment for adults.
Vetencourt said the ability of Prozac and perhaps other SSRIs to return neurons to a more plastic state could, in theory, mean they might also have a role in other neurological disorders in which synaptic plasticity was compromised, including Alzheimer's disease.
The team's findings were published in the journal Science.
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另，细看之下，好像作者说的是百忧解对成人弱视有治疗作用啊 Prozac might cure "lazy eye", scientists say
百忧解可能治疗弱视
LONDON (Reuters) - Prozac, the popular antidepressant, might also be an effective treatment for adults with a "lazy eye", according to new research.
伦敦（路透社）—— 一项最新的研究结果表明，百忧解，一种广泛使用的抗抑郁药，可能对成人弱视也有疗效。
A team of Italian and Finnish scientists said on Thursday that the medicine helped correct the eyesight of rats whose vision had been impaired in early development and it could well do the same for humans.
周三，一组意大利和芬兰科学家表示该药可以提高已在早期发育中被损害的小鼠视力，且对人眼也有一样的疗效。
The medicine appears to work by returning neurons in the adult brain to a more "plastic" state normally only seen in youth. This allows the visual perception system to develop its proper connections between the eye and the brain.
该药依靠使成人大脑神经元更具有只见于年轻人大脑中的可塑性状态而发挥疗效。这使得视知觉系统发育自身眼-脑间的合理联系。
The discovery could also help explain exactly how antidepressants help regulate mood in depressed patients, by suggesting brain plasticity is a key part of the process.
该项发现提示大脑可塑性是这个过程的关键部分，有助于阐明抗抑郁药调节抑郁患者情绪的作用。
Prozac was initially introduced by U.S. drugmaker Eli Lilly and Co in 1987 and belongs to a class of compounds called selective serotonin reuptake inhibitors (SSRIs). It is now off patent and widely available generically as fluoxetine.
百忧解最早于1987年由美国制药商礼来公司生产，属于一类选择性5-羟色胺再摄取抑制剂 (SSRIs)的合成药。该药现已失去专利保护，通用名称为氟西汀而普遍提供。
Jose Fernando Maya Vetencourt from Scuola Normale Superiore in Pisa and colleagues intend to go on to study the drug's curative properties on human eyesight, though definitive clinical trial plans have yet to be developed.
尽管尚未规划明确的临床试验，来自比萨高等师范学院的Jose Fernando Maya Vetencourt及其同事试图继续进行该药对人眼视力的治疗性研究。
"It will take a couple of years, maybe more," he told Reuters.
他告诉路透社记者，这需要好几年，也许更多。
Amblyopia, commonly known as "lazy eye", is the most frequent cause of visual impairment in childhood and affects 2 to 3 percent of children, according to the U.S. National Eye Institute.
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作者:admin@医学,生命科学 2011-01-17 17:14
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