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【Epilepsy】一项历时两年的有关新发癫痫儿童的认
E-mail: hermann@neurology.wisc.edu
Copyright © 2008 by the International League Against Epilepsy
KEYWORDS
Epilepsy • Cognition • Prospective • Development
ABSTRACT
Purpose: To characterize patterns and determinants of normal and abnormal cognitive development in children with new onset epilepsy compared to healthy controls.
Methods: Longitudinal (2-year) cognitive growth was examined in 100 children, age 8–18 years, including healthy controls (n = 48) and children with new onset epilepsy (n = 52). Cognitive maturation was examined as a function of the presence/absence of two neurobehavioral comorbitiies (attention deficit hyperactivity disorder and/or academic problems) identified at the time of epilepsy diagnosis. Groups were compared across a comprehensive neuropsychological battery assessing intelligence, academic achievement, language, memory, executive function, and psychomotor speed.
Results: Children with new onset epilepsy without neurobehavioral comorbidities were comparable to healthy controls at baseline, rate of cognitive development, and follow-up assessment across all neuropsychological domains. In contrast, the presence of neurobehavioral comorbidities was associated with significantly worse baseline and prospective cognitive trajectories across all cognitive domains, especially executive functions.
Conclusion: The presence of neurobehavioral comorbidities at the time of epilepsy onset is a major marker of abnormal cognitive development both prior to and after the onset of epilepsy.
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Accepted May 30, 2008; Online Early publication xxxxxx xx xxxx.
http://www3.interscience.wiley.com/journal/121404189/abstract
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作者:admin@医学,生命科学 2010-10-04 17:11
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