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【medical-news】瑞士研究称常服镇痛药增加患心血
Ibuprofen 'trebles the risk of a stroke' as doctors warn over dangers of long-term use
By Sophie Borland
Last updated at 11:14 AM on 12th January 2011
http://www.dailymail.co.uk/health/article-1346254/Ibuprofen-trebles-risk-stroke-doctors-warn.html
Large regular doses of ibuprofen and similar painkillers could treble the risk of strokes and increase the likelihood of heart attacks, researchers are warning.
Scientists have found high doses of ibuprofen may carry a similar health risk to painkillers that were withdrawn from the market several years ago on safety grounds.
A study found people who had taken ibuprofen over a long period were almost three times as likely to suffer a stroke. Adverts have highlighted facial and arm weakness are early symptoms of stroke
Up to eight million Britons are prescribed so-called anti-inflammatory drugs every year, usually to combat arthritis or back pain.
Doctors stress that the stroke and heart risks only exist for those taking high doses of ibuprofen over long periods – and there is no danger in the odd pill for a headache, for example.
Researchers from the University of Bern in Switzerland looked at more than 31 clinical trials involving 116,429 patients.
They had each taken one of seven commonly-used painkillers, The study, published in the British Medical Journal, found that those who had taken ibuprofen over a long period of time were almost three times as likely to suffer a stroke.
The painkiller was also shown to raise significantly the risk of heart attacks and deaths caused by heart disease.
Another commonly prescribed pill, diclofenac, which is also sold under the trade name Rhumalgan, was shown to almost treble the risk of strokes and increase the likelihood of heart disease related death by four times.
The study also suggested that ibuprofen carried a similar risk of stroke and death from heart disease to rofecoxib, also known as Vioxx, which was withdrawn from the market in 2004 over safety concerns.
Professor Peter Jüni, of the University of Bern, said: ‘We looked at patients taking these drugs three to four times a day.
‘They were mainly being treated for osteoarthritis with a few who had rheumatoid arthritis. A lot of them are elderly who are already have lots of risk factors and these will then be duplicated with these painkillers.
‘In terms of stroke, ibuprofen doesn’t look very good. If I was in chronic pain I would not take it as the risks are just too high. I would look at the different options.’
科学网： http://news.sciencenet.cn/htmlnews/2011/1/242822.shtm
瑞士一项研究表明，长期大量服用镇痛药容易增加罹患心血管疾病风险。不过，偶尔服用镇痛药的普通人不必为此担心。
研究报告1月12日刊登于《英国医学杂志》（BMJ）周刊。
瑞士伯尔尼大学社会与预防医学学院科学家分析31个临床试验项目，其中涉及约11.6万名病患。这些人长期大量服用总共7种常见镇痛药，其中既包括传统药物，也包括新一代药物。
英国《每日邮报》12日引述研究负责人彼得·朱尼教授的话报道：“这些病人每天服用镇痛药三至四次……他们通常是骨关节炎患者，其中一些患有风湿关节炎。
统计结果显示，受调查者中有554人患心脏病、377人中风、676人死亡。
研究人员认为，镇痛药引发心血管问题的绝对风险低，但与服用毫无药效安慰剂的人相比，仍然存在“重大风险”。
朱尼说，接受调查的大部分病患是老年人，“本身面临多种心脑血管疾病风险。镇痛药会让风险加倍”。
研究结果显示，与服用安慰剂的人相比，服用德国默克公司镇痛药“罗非昔布”以及瑞士诺华公司“罗美昔布”的患者，患心脏病的风险多一倍；服用布洛芬患者中风的几率高三倍。
另外，服用默克公司“Arcoxia”以及双氯芬酸的患者，因心血管疾病死亡的几率是服用安慰剂人的四倍。
“尽管存在不确定性，但几乎没有证据证明这些接受调查的药物在心血管方面安全，”朱尼说。
研究人员说，统计结果显示，患关节炎的患者服用萘普生最安全，但这种药有一定副作用，可能引起胃部不适。另外一种相对安全的镇痛药是“西乐葆”，每天服用剂量不应超过400毫克。
朱尼认为，研究结果应该引发医生关注，提醒他们开镇痛药时把心血管疾病风险考虑在内。
爱丁堡大学临床药理学教授西蒙·马克斯韦尔认为，普通人不用过于担心镇痛药风险，“大部分人只是在短时间内服用止痛片，用来缓解短期症状，这样的风险最小”。比如，偶尔服用镇痛药缓解头痛不会带来危险。
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作者:admin@医学,生命科学 2011-01-13 13:47
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