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【medical-news】肾癌引起的死亡在增加
Deaths From Kidney Cancer on the Rise
肾癌引起的死亡在增加
Expert suggests lack of effective chemotherapy drugs might explain trend
专家认为缺少有效的化疗药物可以解释这种现象
Thursday, September 21, 2006
星期四，2006年9月21日
THURSDAY, Sept. 21 (HealthDay News) -- While more kidney cancers are being diagnosed and treated early, the number of deaths from the disease continues to increase, University of Michigan researchers report.
星期四，9月21日（每日健康新闻）――虽然更多的肾癌可以得到早期诊断和早期治疗，然而肾癌引起的死亡率却不断增加，密西根州大学研究人员报道。
The fact that the number of cases has been growing is largely due to the detection of small, presumably curable, tumors, so the scientists said they aren't exactly sure why so many are still dying.
事实是，大量病例不断涌现主要是由于小而可能治愈的肿瘤的检出，所以科学家不能确定为什么还会有很多患者死亡。
However, one expert noted the trend might be explained by the lack of effective chemotherapy drugs to give kidney cancer patients once they have had surgery to remove tumors.
然而，一位专家指出，肾癌患者手术切除肿瘤后缺少有效的化疗药可以用来解释这种情况。
Kidney cancer is the third most common cancer of the reproductive and urinary systems. There will be some 38,890 new cases of kidney cancer in the United States this year, and some 12,840 people will die from the disease, the American Cancer Society estimates.
肾癌在生殖泌尿系统最常见肿瘤中位居第三。美国肿瘤协会预计，美国今年将有38，890新病例，12，840位患者将死于这种疾病。
The latest research was published in the Sept. 20 issue of the Journal of the National Cancer Institute.
最新的研究成果发表在《国家肿瘤协会》杂志9月刊第20期。
"With increased early detection and treatment of small tumors, we would expect to see a decrease in mortality associated with kidney cancer," study senior author Dr. Brent K. Hollenbeck said in a statement. "Surprisingly, that's not what we found. Our research shows that an increase in detection and treatment is not leading to a reduction in the kidney cancer mortality rate."
本研究资深作者Brent K. Hollenbeck博士在一项声明中说：“随着小肿瘤早期诊断治疗的不断提高，我们希望与肾癌相关的死亡能够减少，然而令人惊讶的是我们的研究结果并不是这样。我们的研究发现，早期诊断和治疗的提高并没有降低肾癌的死亡率”
In the study, Hollenbeck's team collected data on 34,503 patients who had kidney cancer.
在本研究中，Hollenbeck研究小组搜集了34，503名肾癌患者的资料。
They found that from 1983 to 2002, the incidence of kidney cancer increased 52 percent, from 7.1 to 10.8 cases per 100,000 people. The biggest increase was seen in the number of people with small tumors, roughly 2 centimeters to 4 centimeters in size.
他们发现，从1983年到2002年，肾癌的发病率增加了52％，从7.1/10万人上升到10.8/10万人。2~4厘米之间小肿瘤患者的数目上升最快。
However, death rates also went up, most notably among those with tumors larger than 7 centimeters. Overall, deaths from kidney cancer rose from 1.2 to 3.2 per 100,000 people, the researchers noted.
然而，死亡率还在增加，其中死亡率增加最显著的是大于7厘米的肿瘤患者。总之，肾癌导致的死亡人数从1.2/10万人上升到了3.2/10万人。研究人员说道。
These findings are partly explained by increasing incidence of larger, more lethal tumors. "While more and more small, detectable kidney tumors are being treated, the absolute number of patients with larger, lethal masses has not decreased. And it is these larger, lethal masses that seem to mainly affect mortality," study co-author Dr. John M. Hollingsworth said in a statement.
体积较大而且致死性强的肿瘤发生率不断增加的现象很大程度上解释了这些发现。共同作者John M. Hollingsworth博士在一项声明中说：“虽然越来越多可探测的小肿瘤患者得到治疗，肿瘤体积较大且致死性强的患者的绝对数目并没有减少。而恰恰主要是这些体积较大而且致死性强的肿瘤影响死亡率”
In addition, some of the smaller tumors may not need surgical removal, the researchers speculated.
另外，研究者认为一些较小的肿瘤可能不需要手术切除。
"We're not saying that surgery for patients with small renal masses is inappropriate," Hollingsworth said. "Our findings, however, show that their increased treatment has not diminished kidney cancer mortality. This calls to question the effectiveness of our current treatment strategy. Perhaps there are some patients with small kidney tumors for whom surgery is not the best option."
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作者:admin@医学,生命科学 2010-12-24 15:23
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