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【每日动态】【综述】氢气的选择性抗氧化：动
从2007年日本学者发现氢气选择性抗氧化效应以来，目前该领域的论文呈现爆发式增长，07年2篇，08年8篇，09年20篇，2010年竟然有40篇论文，而且有2篇比较系统介绍氢气医学进展的综述。相信2011年的论文数量将达到60-80篇这样的规模，其中综述性文章将达到5-10篇，各个国家的学者将会不断总结这个领域的研究进展。使氢气医学研究增加更多的关注。
该综述全文
Hydrogen as a Selective Antioxidant: a Review of Clinical and Experimental Studies.Authors: Hong, Y.1; Chen, S.1; Zhang, J-M.1
Source: The Journal of International Medical Research, Volume 38, Number 6, November 2010 , pp. 1893-1903(11)
Abstract:
Oxidative stress is implicated in the pathogenesis of many diseases; however, currently used antioxidants have a high toxicity that constrains administration to a narrow window of therapeutic dosage. There is a clear need for more effective and safer antioxidants. Diatomic hydrogen (H2) was proposed as a novel antioxidant that selectively reduces levels of toxic reactive-oxygen species. Recently, many studies have reported that H2 (inhaled or orally ingested, typically as approximately 0.8 mM H2-saturated water), can exert beneficial effects in diverse animal models of ischaemia-reperfusion injury, and inflammatory and neurological disease. In the clinic, oral administration of H2-saturated water is reported to improve lipid and glucose metabolism in subjects with diabetes or impaired glucose tolerance; promising results have also been obtained in reducing inflammation in haemodialysis patients and treating metabolic syndrome. These studies suggest H2 has selective antioxidant properties, and can exert antiapoptotic, antiinflammatory and antiallergy effects. This review summarizes recent research findings and mechanisms concerning the therapeutic potential of H2.
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作者:admin@医学,生命科学 2011-01-11 12:26
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