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【Clin Cancer Res】靶向IKK与IKK相关激酶的肿瘤治疗
Abstract
IB kinases (IKK) and IKK-related kinases play critical roles in regulating the immune response through nuclear factor-B and IFN regulatory factor–dependent signaling transduction cascades. Recently, these kinases have been implicated in the pathogenesis of many human diseases, including cancer. In fact, dysregulation of IKK activities promotes tumor survival, proliferation, migration, metastasis, and angiogenesis—common characteristics of many types of human cancers. Because of their oncogenic effects in human cancer development, targeting IKK and IKK-related kinases is becoming an increasingly popular avenue for the development of novel therapeutic interventions for cancer. This review will briefly cover the recent discovery of the downstream substrates of IKK and IKK-related kinases, and outline the strategies used for targeting IKK as a therapeutic intervention for cancer.
http://clincancerres.aacrjournals.org/cgi/content/abstract/14/18/5656 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Advances in Targeting IKK and IKK-Related Kinases for Cancer Therapy
靶向IKK和IKK相关性激酶在癌症治疗中进展
IB kinases (IKK) and IKK-related kinases play critical roles in regulating the immune response through nuclear factor-B and IFN regulatory factor–dependent signaling transduction cascades. Recently, these kinases have been implicated in the pathogenesis of many human diseases, including cancer. In fact, dysregulation of IKK activities promotes tumor survival, proliferation, migration, metastasis, and angiogenesis—common characteristics of many types of human cancers. Because of their oncogenic effects in human cancer development, targeting IKK and IKK-related kinases is becoming an increasingly popular avenue for the development of novel therapeutic interventions for cancer. This review will briefly cover the recent discovery of the downstream substrates of IKK and IKK-related kinases, and outline the strategies used for targeting IKK as a therapeutic intervention for cancer.
IB激酶（IKK）和IKK相关性激酶通过NF-β和INF调控因子依赖性激酶信号转导级联反应在调控免疫反应中发挥重要作用，最近，这些激酶参与了许多人来疾病包括癌症的病理发生。实际上，IKK活性失调促进了肿瘤生存、增殖、迁移、转移和血管生成，而这些是许多人类癌症常见的特征。由于他们在人来癌症发展中的致癌作用，靶向IKK和IKK相关激酶正成为癌症治疗的一种较为流行的方法。这篇综述将简要概述IKK和IKK相关激酶的下游底物的最新研究，概述了靶向IKK作为癌症治疗的策略。 靶向IKK和IKK相关性激酶在癌症治疗中进展
IB激酶（IKK）和IKK相关性激酶通过NF-β和INF调控因子依赖性激酶信号转导级联反应在调控免疫反应中发挥重要作用，最近，这些激酶参与了许多人来疾病包括癌症的病理发生。实际上，IKK活性失调促进了肿瘤生存、增殖、迁移、转移和血管生成，而这些是许多人类癌症常见的特征。由于他们在人来癌症发展中的致癌作用，靶向IKK和IKK相关激酶正成为癌症治疗的一种较为流行的方法。这篇综述将简要概述IKK和IKK相关激酶的下游底物的最新研究，概述了靶向IKK作为癌症治疗的策略。
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作者:admin@医学,生命科学 2010-10-02 17:11
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