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【medical-news】亚洲建立多重H5N1禽流感病毒监测：
Author: Chen, H; Smith, GJD; Li, KS, et al.
Source: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Volume: 103 Issue: 8 Pages: 2845-2850 Published: FEB 21 2006
Times Cited: 144
Preparedness for a possible influenza pandemic caused by highly pathogenic avian influenza A subtype H5N1 has become a global priority. The spread of the virus to Europe and continued human infection in Southeast Asia have heightened pandemic concern. It remains unknown from where the pandemic strain may emerge; current attention is directed at Vietnam, Thailand, and, more recently, Indonesia and China. Here, we report that genetically and antigenically distinct sublineages of H5N1 virus have become established in poultry in different geographical regions of Southeast Asia, indicating the long-term endemicity of the virus, and the isolation of H5N1 virus from apparently healthy migratory birds in southern China. Our data show that H5N1 influenza virus, has continued to spread from its established source in southern China to other regions through transport of poultry and bird migration. The identification of regionally distinct sublineages contributes to the understanding of the mechanism for the perpetuation and spread of H5N1, providing information that is directly relevant to control of the source of infection in poultry. It points to the necessity of surveillance that is geographically broader than previously supposed and that includes H5N1 viruses of greater genetic and antigenic diversity. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title: Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control
亚洲建立多重H5N1禽流感病毒监测：开始流行病控制
Author : Chen, H; Smith, GJD; Li, KS, et al.
Source: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Volume: 103 Issue: 8 Pages: 2845-2850 Published: FEB 21 2006
Times Cited: 144
Preparedness for a possible influenza pandemic caused by highly pathogenic avian influenza A subtype H5N1 has become a global priority. The spread of the virus to Europe and continued human infection in Southeast Asia have heightened pandemic concern. It remains unknown from where the pandemic strain may emerge; current attention is directed at Vietnam, Thailand, and, more recently, Indonesia and China. Here, we report that genetically and antigenically distinct sublineages of H5N1 virus have become established in poultry in different geographical regions of Southeast Asia, indicating the long-term endemicity of the virus, and the isolation of H5N1 virus from apparently healthy migratory birds in southern China. Our data show that H5N1 influenza virus, has continued to spread from its established source in southern China to other regions through transport of poultry and bird migration. The identification of regionally distinct sublineages contributes to the understanding of the mechanism for the perpetuation and spread of H5N1, providing information that is directly relevant to control of the source of infection in poultry. It points to the necessity of surveillance that is geographically broader than previously supposed and that includes H5N1 viruses of greater genetic and antigenic diversity.
针对高致病性禽流感病毒A亚型H5N1可能导致的流感大流行的准备已经成为全球最优先考虑的事情。病毒继续向欧洲的传播及在东南亚人群中的持续感染使人们对大流行顾虑万分。大流行的倾向可能在何处爆发，目前仍不可知；当前的关注重点在越南、泰国，最近是印度尼西亚和中国。此处，我们报告了在东南亚不同地域的家禽中建立了基因学和病原学上都有所不同的H5N1病毒的亚型，这说明该病毒长期的地域性传播，并且在中国南方明显健康的迁徙鸟类中分离出H5N1病毒。我们的数据显示，H5N1流感病毒已经持续的从它在中国南方的发源地通过家禽和鸟类迁徙向其他地域进行传播。地域性不同亚群的确认有助于理解H5N1长期存在和传播的机制，提供了与在家禽中控制传染源直接相关的信息。这些数据指出，对比以往认为的更广大的地域及更多基因和病原性变化的H5N1病毒进行监控的必要性。
亚洲建立多重H5N1禽流感病毒监测：开始流行病控制
针对高致病性禽流感病毒A亚型H5N1可能导致的流感大流行的准备已经成为全球最优先考虑的事情。病毒继续向欧洲的传播及在东南亚人群中的持续感染使人们对大流行顾虑万分。大流行的倾向可能在何处爆发，目前仍不可知；当前的关注重点在越南、泰国，最近是印度尼西亚和中国。此处，我们报告了在东南亚不同地域的家禽中建立了基因学和病原学上都有所不同的H5N1病毒的亚型，这说明该病毒长期的地域性传播，并且在中国南方明显健康的迁徙鸟类中分离出H5N1病毒。我们的数据显示，H5N1流感病毒已经持续的从它在中国南方的发源地通过家禽和鸟类迁徙向其他地域进行传播。地域性不同亚群的确认有助于理解H5N1长期存在和传播的机制，提供了与在家禽中控制传染源直接相关的信息。这些数据指出，对比以往认为的更广大的地域及更多基因和病原性变化的H5N1病毒进行监控的必要性。
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作者:admin@医学,生命科学 2011-06-11 17:27
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