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【文摘发布】糖尿病的长期影响及认知能力的治
TITLE: Long-Term Effect of Diabetes and Its Treatment on Cognitive Function:The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group
ABSTRACT
Background Long-standing concern about the effects of type 1 diabetes on cognitive ability has increased with the use of therapies designed to bring glucose levels close to the nondiabetic range and the attendant increased risk of severe hypoglycemia.
Methods A total of 1144 patients with type 1 diabetes enrolled in the Diabetes Control and Complications Trial (DCCT) and its follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) study were examined on entry to the DCCT (at mean age 27 years) and a mean of 18 years later with the same comprehensive battery of cognitive tests. Glycated hemoglobin levels were measured and the frequency of severe hypoglycemic events leading to coma or seizures was recorded during the follow-up period. We assessed the effects of original DCCT treatment-group assignment, mean glycated hemoglobin values, and frequency of hypoglycemic events on measures of cognitive ability, with adjustment for age at baseline, sex, years of education, length of follow-up, visual acuity, self-reported sensory loss due to peripheral neuropathy, and (to control for the effects of practice) the number of cognitive tests taken in the interval since the start of the DCCT.
Results Forty percent of the cohort reported having had at least one hypoglycemic coma or seizure. Neither frequency of severe hypoglycemia nor previous treatment-group assignment was associated with decline in any cognitive domain. Higher glycated hemoglobin values were associated with moderate declines in motor speed (P=0.001) and psychomotor efficiency (P<0.001), but no other cognitive domain was affected.
Conclusions No evidence of substantial long-term declines in cognitive function was found in a large group of patients with type 1 diabetes who were carefully followed for an average of 18 years, despite relatively high rates of recurrent severe hypoglycemia. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 TITLE: Long-Term Effect of Diabetes and Its Treatment on Cognitive Function:The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group
标题：DCCT/EDIC研究：糖尿病及其治疗对认知能力的长期影响
RESOURCE: NEJM,Volume 356:1842-1852 May 3, 2007 Number 18
ABSTRACT
摘要
Background Long-standing concern about the effects of type 1 diabetes on cognitive ability has increased with the use of therapies designed to bring glucose levels close to the nondiabetic range and the attendant increased risk of severe hypoglycemia.
背景：由于使血糖水平接近非糖尿病患者的范围的治疗方法的应用及随之增加了发生严重的低血糖的风险，增加了对于长期以来一直处于静止状态的关于1型糖尿病对认知能力的影响的关注度。
Methods A total of 1144 patients with type 1 diabetes enrolled in the Diabetes Control and Complications Trial (DCCT) and its follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) study were examined on entry to the DCCT (at mean age 27 years) and a mean of 18 years later with the same comprehensive battery of cognitive tests. Glycated hemoglobin levels were measured and the frequency of severe hypoglycemic events leading to coma or seizures was recorded during the follow-up period. We assessed the effects of original DCCT treatment-group assignment, mean glycated hemoglobin values, and frequency of hypoglycemic events on measures of cognitive ability, with adjustment for age at baseline, sex, years of education, length of follow-up, visual acuity, self-reported sensory loss due to peripheral neuropathy, and (to control for the effects of practice) the number of cognitive tests taken in the interval since the start of the DCCT.
方法：糖尿病控制及其并发症试验(DCCT)及糖尿病介入治疗和并发症的流行病学研究（EDIC）的随访研究一共登记了1144例1型糖尿病患者，在登记入DCCT时（平均年龄27岁）及18年后做了相同范围的认知能力的测试。在随访期间，测定了糖化血红蛋白水平，并记录了严重低血糖导致的昏迷或癫痫发作的频度。我们评估在不同年龄、性别、教育年数、随访时间、视力、自我报告的由于周围神经病导致的感觉缺失、从DCCT开始期间实施认知能力测试的次数（为了控制练习的影响）情况下，最初DCCT治疗组的分配、糖化血红蛋白平均值和低血糖发生的频度对衡量认知能力的影响。
Results Forty percent of the cohort reported having had at least one hypoglycemic coma or seizure. Neither frequency of severe hypoglycemia nor previous treatment-group assignment was associated with decline in any cognitive domain. Higher glycated hemoglobin values were associated with moderate declines in motor speed (P=0.001) and psychomotor efficiency (P<0.001), but no other cognitive domain was affected.
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作者:admin@医学,生命科学 2011-06-09 17:21
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