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【文摘发布】人类肠病毒71型感染，来自于马来西
Author: Ooi MH, Wong SC, Podin Y, Akin W, del Sel S, Mohan A, Chieng CH, Perera D, Clear D, Wong D, Blake E, Cardosa J, Solomon T.
Sourse: Clin Infect Dis. 2007 Mar 1;44(5):646-56. Epub 2007 Jan 22
BACKGROUND: Human enterovirus (HEV)-71 causes large outbreaks of hand-foot-and-mouth disease with central nervous system (CNS) complications, but the role of HEV-71 genogroups or dual infection with other viruses in causing severe disease is unclear. METHODS: We prospectively studied children with suspected HEV-71 (i.e., hand-foot-and-mouth disease, CNS disease, or both) over 3.5 years, using detailed virological investigation and genogroup analysis of all isolates. RESULTS: Seven hundred seventy-three children were recruited, 277 of whom were infected with HEV-71, including 28 who were coinfected with other viruses. Risk factors for CNS disease in HEV-71 included young age, fever, vomiting, mouth ulcers, breathlessness, cold limbs, and poor urine output. Genogroup analysis for the HEV-71-infected patients revealed that 168 were infected with genogroup B4, 68 with C1, and 41 with a newly emerged genogroup, B5. Children with HEV-71 genogroup B4 were less likely to have CNS complications than those with other genogroups (26 [15%] of 168 vs. 30 [28%] of 109; odds ratio [OR], 0.48; 95% confidence interval [CI], 0.26-0.91; P=.0223) and less likely to be part of a family cluster (12 [7%] of 168 vs. 29 [27%] of 109; OR, 0.21; 95% CI, 0.10-0.46; P<.0001); children with HEV-71 genogroup B5 were more likely to be part of a family cluster (OR, 6.26; 95% CI, 2.77-14.18; P<.0001). Children with HEV-71 and coinfected with another enterovirus or adenovirus were no more likely to have CNS disease. CONCLUSIONS: Genogroups of HEV-71 may differ with regard to the risk of causing CNS disease and the association with family clusters. Dual infections are common, and all possible causes should be excluded before accepting that the first virus identified is the causal agent.
Publication Types:
Research Support, Non-U.S. Gov't
PMID: 17278054 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领
另外题目翻译错误，应该为前瞻性研究而非回顾性 Title: Human enterovirus 71 disease in Sarawak, Malaysia: a prospective clinical, virological, and molecular epidemiological study
题目：人类肠病毒71型感染，来自于马来西亚的前瞻性临床、病毒学及分子流行病研究
Author: Ooi MH, Wong SC, Podin Y, Akin W, del Sel S, Mohan A, Chieng CH, Perera D, Clear D, Wong D, Blake E, Cardosa J, Solomon T.
作者：Ooi MH, Wong SC, Podin Y, Akin W, del Sel S, Mohan A, Chieng CH, Perera D, Clear D, Wong D, Blake E, Cardosa J, Solomon T.
Sourse: Clin Infect Dis. 2007 Mar 1;44(5):646-56. Epub 2007 Jan 22
来源：《临床感染病学》. 2007 Mar 1;44(5):646-56. Epub 2007 Jan 22
BACKGROUND: Human enterovirus (HEV)-71 causes large outbreaks of hand-foot-and-mouth disease with central nervous system (CNS) complications, but the role of HEV-71 genogroups or dual infection with other viruses in causing severe disease is unclear.
背景：人类肠病毒71型能引起伴有中枢神经系统（CNS）并发症的手足口病的大规模爆发，但HEV-71基因组或与其他病毒引起的双重感染引发严重疾病的机制尚不清楚。
METHODS: We prospectively studied children with suspected HEV-71 (i.e., hand-foot-and-mouth disease, CNS disease, or both) over 3.5 years, using detailed virological investigation and genogroup analysis of all isolates.
方法：我们对可疑HEV-71感染（即患手足口病、CNS疾病或者两者均有）的儿童做了为期超过三年半的前瞻性研究并对所有的隔离者进行了详尽的病毒学检查和基因组分析。
RESULTS: Seven hundred seventy-three children were recruited, 277 of whom were infected with HEV-71, including 28 who were coinfected with other viruses.
结果：（本研究）共纳入773名儿童，277名有HEV-71感染，其中包括28名被其他病毒复合感染的（儿童）。
Risk factors for CNS disease in HEV-71 included young age, fever, vomiting, mouth ulcers, breathlessness, cold limbs, and poor urine output.
易引起HEV-71感染者发生CNS疾病的危险因素包括年龄小、发热、呕吐、口腔溃疡、呼吸困难、四肢发冷和少尿。
Genogroup analysis for the HEV-71-infected patients revealed that 168 were infected with genogroup B4, 68 with C1, and 41 with a newly emerged genogroup, B5.
对HEV-71感染患者进行的基因组分析显示168名感染了基因组B4型，68名感染了C1型，41名感染了新近出现的基因组B5型。
Children with HEV-71 genogroup B4 were less likely to have CNS complications than those with other genogroups (26 [15%] of 168 vs. 30 [28%] of 109; odds ratio [OR], 0.48; 95% confidence interval [CI], 0.26-0.91; P=.0223) and less likely to be part of a family cluster (12 [7%] of 168 vs. 29 [27%] of 109; OR, 0.21; 95% CI, 0.10-0.46; P<.0001);
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作者:admin@医学,生命科学 2011-05-05 17:46
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