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【medical-news】脉压：心脏手术后卒中风险的有力
By Martha Kerr
NEW YORK (Reuters) Oct 29 - Preoperative brachial pulse pressure, an index of vascular stiffness, is a strong predictor of stroke following cardiac surgery, and it is independent of chronological age, a Johns Hopkins team reports in the October issue of Hypertension.
In a retrospective review, Dr. Daniel Nyhan at Johns Hopkins Hospital in Baltimore, Maryland, and colleagues assessed stroke risk factors in 703 patients who underwent cardiac surgery and were followed for a mean of 348 days. During that time, 42 patients experienced a stroke.
Stroke patients had a significantly higher average pulse pressure (81.2 mm Hg) compared with patients who did not have strokes (64.5 mm Hg).
The unadjusted hazard ratio for stroke was 1.32 for every 10 mm Hg increase in pulse pressure. "This relationship remained highly significant (HR: 2.62 for each 10 mm Hg increase in pulse pressure) in the adjusted model, which included age," the team reports.
Stroke-free survival was significantly higher if pulse pressure was less than 72 mm Hg compared with a pulse pressure greater than 72 mm Hg.
Co-investigator Dr. Dan E. Berkowitz told Reuters Health that "vascular stiffness is increasingly recognized as a risk factor for cardiovascular disease...Vascular age, rather than chronological age, is the primary factor affecting stiffness."
Diet, lifestyle modification and blood pressure medications mitigate stroke risk in the long-term. "In the short term, for the cardiac surgery patient, it's important to maintain blood flow to the brain," Dr. Berkowitz said.
Dr. Nyhan commented that "hypoperfusion appears to increase risk of stroke in cardiac surgery," and that it may be beneficial if the blood pressure is kept somewhat high while the patient is on the heart-lung bypass machine.
Hypertension 2007;50:630-635.
http://www.medscape.com/viewarticle/565031 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Pulse Pressure Predicts Risk of Stroke After Cardiac Surgery
脉压是心脏手术后中风的预测因子
By Martha Kerr
By Martha Kerr
NEW YORK (Reuters) Oct 29 - Preoperative brachial pulse pressure, an index of vascular stiffness, is a strong predictor of stroke following cardiac surgery, and it is independent of chronological age, a Johns Hopkins team reports in the October issue of Hypertension.
纽约（路透通讯社）10月29日- Johns Hopkins团队在10月的高血压杂志报导，术前手臂的脉压，血管僵硬度的指标，是心脏术后中风的强有力的预测因子，独立于实足年龄。
In a retrospective review, Dr. Daniel Nyhan at Johns Hopkins Hospital in Baltimore, Maryland, and colleagues assessed stroke risk factors in 703 patients who underwent cardiac surgery and were followed for a mean of 348 days. During that time, 42 patients experienced a stroke.
在回顾性研究中，马里兰Baltimore 的Johns Hopkins医院的 Dr. Daniel Nyhan及同事对进行心脏手术的703患者平均随访348天，评价中风的危险因子。随访期有42例患者发生中风。
Stroke patients had a significantly higher average pulse pressure (81.2 mm Hg) compared with patients who did not have strokes (64.5 mm Hg).
与未发生中风者(64.5 mm Hg)相比，中风者(81.2 mm Hg)的平均脉压更高
The unadjusted hazard ratio for stroke was 1.32 for every 10 mm Hg increase in pulse pressure. "This relationship remained highly significant (HR: 2.62 for each 10 mm Hg increase in pulse pressure) in the adjusted model, which included age," the team reports.
脉压每增加10mmHg，中风者未校正的风险比增加1.32.“校正年龄的校正模型中，两者仍非常显著（脉压每增加10mmHg，HR增加2.62）”
Stroke-free survival was significantly higher if pulse pressure was less than 72 mm Hg compared with a pulse pressure greater than 72 mm Hg.
与脉压高于72mmHg者相比，脉压低于72mmHg者未发生中风者显著增多。
Co-investigator Dr. Dan E. Berkowitz told Reuters Health that "vascular stiffness is increasingly recognized as a risk factor for cardiovascular disease...Vascular age, rather than chronological age, is the primary factor affecting stiffness."
一起进行此研究者Dr. Dan E. Berkowitz告诉路透社健康“血管僵硬度逐渐被看作是心血管疾病的危险因子。。。。。。血管年龄，面非实足年龄，是影响僵硬度的主要因素。”
Diet, lifestyle modification and blood pressure medications mitigate stroke risk in the long-term. "In the short term, for the cardiac surgery patient, it's important to maintain blood flow to the brain," Dr. Berkowitz said.
饮食，生活方式改变和血压药物治疗减轻长期中风的危险。Dr. Dan E. Berkowitz 说“对于心脏手术患者，短期内维持脑灌注是很重要的。”
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作者:admin@医学,生命科学 2011-04-30 05:11
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