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【medical-news】手术以局部控制四肢和躯干类结缔
Shido Y, Nishida Y, Nakashima H, Katagiri H, Sugiura H, Yamada Y, Ishiguro N.
Arch Orthop Trauma Surg. 2008 Sep 23
http://www.ncbi.nlm.nih.gov/sites/entrez
Introduction Surgical treatment has been the mainstay for extremity and trunk desmoid tumors with a negative surgical margin. However, even when resection with a wide surgical margin is achieved, the local recurrence rate remains high. The purpose of this study was to analyze the clinical outcome of patients with extremity and trunk desmoid tumors after surgical treatment and to determine the factors influencing local recurrence.
Materials and methods Between January 1991 and December 2003, 30 of 58 patients with desmoid tumors referred to our institutions and surgically treated and followed up for more than 2 years were selected for this study. Patient age, gender, tumor size, location, status of disease (primary or recurrent), and surgical margins were analyzed as possible risk factors for recurrence.
Results Sixteen (53%) of the 30 patients had a local recurrence. Eight of the 19 patients (42.1%) with a negative surgical margin experienced a recurrence. Younger age (<30 years) was a significant risk factor for local recurrence (P < 0.05). Tumor size, surgical margin and previous surgical history were not associated with local recurrence. Younger age and female gender had a propensity for local recurrence, suggesting that the biological behavior of desmoid tumor may depend on the status of the disease at presentation.
Conclusions These results suggest that radical surgical treatment causing severe functional impairment should be avoided in selected cases on the basis of patient characteristics, and that other novel therapeutic tools may be necessary for patients in whom a higher risk of local recurrence is assumed or severe complications after surgical treatment are predicted. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Surgical treatment for local control of extremity and trunk desmoid tumors
手术局部控制四肢及躯干韧带样瘤
Introduction Surgical treatment has been the mainstay for extremity and trunk desmoid tumors with a negative surgical margin.
前言 四肢及躯干韧带样瘤手术范围主要依据肿瘤切缘阴性。
However, even when resection with a wide surgical margin is achieved, the local recurrence rate remains high.
然而，即使扩大了手术范围，肿瘤局部复发率仍然很高。
The purpose of this study was to analyze the clinical outcome of patients with extremity and trunk desmoid tumors after surgical treatment and to determine the factors influencing local recurrence.
本研究目的：分析四肢及躯干韧带样瘤患者术后临床结果，确定影响复发的因素。
Materials and methods Between January 1991 and December 2003, 30 of 58 patients with desmoid tumors referred to our institutions and surgically treated and followed up for more than 2 years were selected for this study.
材料与方法 自1991年1月至2003年11月，共有58例韧带样瘤在本院就诊行手术切除，且随访2年以上，选择其中30例为研究对象。
Patient age, gender, tumor size, location, status of disease (primary or recurrent), and surgical margins were analyzed as possible risk factors for recurrence.
分析影响复发可能风险因子如患者年龄、性别、肿瘤大小、部位、疾病状态（原发或复发）及切缘。
Results Sixteen (53%) of the 30 patients had a local recurrence. Eight of the 19 patients (42.1%) with a negative surgical margin experienced a recurrence. Younger age (<30 years) was a significant risk factor for local recurrence (P < 0.05).
结果 30例患者中有16例局部复发（53%），手术切缘阴性患者19例中有8例复发，较年青者（小于30岁）为局部复发明显的风险因子。
Tumor size, surgical margin and previous surgical history were not associated with local recurrence. Younger age and female gender had a propensity for local recurrence, suggesting that the biological behavior of desmoid tumor may depend on the status of the disease at presentation.
肿瘤大小、手术切缘和既往手术史与局部复发无关。较年青者和女性有复发倾向，表明韧带样瘤的生物学行为主要依靠疾病特征表现。
Conclusions These results suggest that radical surgical treatment causing severe functional impairment should be avoided in selected cases on the basis of patient characteristics, and that other novel therapeutic tools may be necessary for patients in whom a higher risk of local recurrence is assumed or severe complications after surgical treatment are predicted.
结论 研究表明，依据患者特征选择彻底切除病例，可以避免由此导致的严重功能损害，对确定局部复发有高风险或预计术后有严重并发症者，有必要应用其它新的治疗手段。 手术局部控制四肢及躯干韧带样瘤
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作者:admin@医学,生命科学 2011-04-29 17:11
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