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【medical-news】专家建议用Hb A1C 筛查诊断糖尿病
BALTIMORE, Md -- July 31, 2008 -- The haemoglobin (Hb) A1C test may have far wider use in identifying millions with undetected diabetes, according to a study in the July issue of the Journal of Clinical Endocrinology and Metabolism.
"The test is a measure of long-term glucose control, but doctors don't typically use it to screen for or diagnose the disease," said Christopher Saudek, MD, Johns Hopkins University School of Medicine and Johns Hopkins Comprehensive Diabetes Center, Baltimore, Maryland.
"There's reason to believe it could help identify many of the estimated 6 million people in the United States who have diabetes but don't know it."
The current screening and diagnostic tests are accurate only if patients fast for at least 10 hours before the test. Therefore, the test might miss a significant portion of people who have diabetes or who are at high risk for developing the disease since glucose levels will vary depending on diet and exercise regimen for several days leading up to the blood draw.
"If a patient is scheduled for a physical, he or she may 'tune up' by changing the regimen for a few days and throw off their test results, causing doctors to miss the patient's usual pattern of high blood sugar," Dr. Saudek said.
Dr. Saudek and colleagues concluded that the Hb A1C test should be used as a front-line method for identifying patients with diabetes, especially for those at high risk for the disease. Since the test does not require fasting and isn't affected by short-term changes in diet and exercise, the Hb A1C test has significant advantages to current testing methods.
The consensus was reached by a panel of endocrinologists, pathologists, and internists who reviewed relevant published studies and available tests.
The panel recommends that individuals who score at least 6% on an Hb A1C test may have or be at risk for diabetes and should be tracked with additional glucose or Hb A1C tests. Those who score between 6.5% or above, if confirmed, should be considered to have diabetes.
"This is a first step toward changing medical practice and could greatly enhance how well we're able to identify people with diabetes," said Dr. Saudek.
SOURCE: Johns Hopkins Medical Institutions
http://www.docguide.com/news/content.nsf/news 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Panel Recommends Using Hb A1C to Screen for Diabetes
专家组建议用Hb A1C 筛查诊断糖尿病
BALTIMORE, Md -- July 31, 2008 -- The haemoglobin (Hb) A1C test may have far wider use in identifying millions with undetected diabetes, according to a study in the July issue of the Journal of Clinical Endocrinology and Metabolism.
BALTIMORE, Md——2008年7月31日——根据《临床内分泌学与代谢杂志》7月刊的一项研究，在鉴别上百万未明确的糖尿病者方面，血红蛋白A1C的检测可能有更广泛的用途。
"The test is a measure of long-term glucose control, but doctors don't typically use it to screen for or diagnose the disease," said Christopher Saudek, MD, Johns Hopkins University School of Medicine and Johns Hopkins Comprehensive Diabetes Center, Baltimore, Maryland.
“虽然这项检测是血糖长期控制的指标，但医生并不常用它筛选或者诊断这种疾病。” Christopher Saudek说。他是美国马里兰州巴尔的摩约翰霍普金斯大学医学院和约翰霍普金斯综合糖尿病中心的医学博士。
"There's reason to believe it could help identify many of the estimated 6 million people in the United States who have diabetes but don't know it."
“有理由相信它能帮助诊断尚未发现的糖尿病患者。在美国这样的人估计有6百万。
The current screening and diagnostic tests are accurate only if patients fast for at least 10 hours before the test. Therefore, the test might miss a significant portion of people who have diabetes or who are at high risk for developing the disease since glucose levels will vary depending on diet and exercise regimen for several days leading up to the blood draw.
只有当患者在检测前空腹至少十个小时，目前的筛选和诊断试验是精确的。并且，这试验将漏掉已有糖尿病或有糖尿病高风险的患者中重要的一块——由于几天饮食和运动调节导致血糖水平的变化。
"If a patient is scheduled for a physical, he or she may 'tune up' by changing the regimen for a few days and throw off their test results, causing doctors to miss the patient's usual pattern of high blood sugar," Dr. Saudek said.
“如果患者预约了内科医生，他或她可能会改变几天生活方式来进行调整，从而摆脱他们的试验结果，导致医生错过了患者通常高血糖的状况。” Saudek医生说。
Dr. Saudek and colleagues concluded that the Hb A1C test should be used as a front-line method for identifying patients with diabetes, especially for those at high risk for the disease. Since the test does not require fasting and isn't affected by short-term changes in diet and exercise, the Hb A1C test has significant advantages to current testing methods.
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作者:admin@医学,生命科学 2011-04-26 05:14
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