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【文摘发布】肺多原发癌：发病率逐渐增加并需
Synchronous multiple primary lung cancer: an increasing clinical occurrence requiring multidisciplinary management.
J Thorac Cardiovasc Surg. 2007 May;133(5):1193-200
Trousse D, Barlesi F, Loundou A, Tasei AM, Doddoli C, Giudicelli R, Astoul P, Fuentes P, Thomas P.
Department of Thoracic Surgery, Sainte Marguerite University Hospital, Marseille, France.
OBJECTIVE: No guidelines detailing recommendations for the selection and treatment of patients with synchronous multiple primary lung cancer have been published. We report on a single-institution experience with synchronous multiple primary lung cancer, with emphasis on long-term survival. METHODS: We performed a retrospective study of 125 consecutive patients with synchronous multiple primary lung cancer who underwent operation between 1985 and 2006. Various treatment strategies were applied, including perioperative therapy. Potential prognosticators were submitted to univariate and multivariate analyses. RESULTS: Tumors were bilateral (n = 34) or ipsilateral (n = 91). Optimal surgical treatment (complete anatomic resection with radical lymphadenectomy) was possible in 65.6% of the cases. pN0 disease was present in 32.3% of the patients; 30-day and 90-day mortality rates were 4.5% and 11%, respectively. Two- and 5-year overall survivals were 61.6% and 34%, respectively, with a median survival of 35 months. On univariate analysis, smoking status, high Charlson index, low forced expiratory volume in 1 second, occurrence of postoperative complications, and performance of a pneumonectomy affected the overall survival adversely. Conversely, bilateral disease, location in the same lobe, and pN0 disease were favorable prognosticators. On multivariate analysis, low forced expiratory volume in 1 second, nonoptimal surgical treatment, and performance of a pneumonectomy were independent predictors of poor long-term survival, whereas female sex, younger age, asymptomatic disease, pN0 status, and performance of an adjuvant treatment affected the survival favorably. CONCLUSIONS: Provided there is an appropriate selection process, patients with synchronous multiple primary lung cancer are expected to benefit from surgery. Optimal surgery should be performed, but pneumonectomy should be avoided whenever possible. Adjuvant treatment is suggested to provide an added survival advantage.
PMID: 17467428 [PubMed - in process]
链接：http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17467428&itool=iconabstr&query_hl=1&itool=pubmed_docsum 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 title:
Synchronous multiple primary lung cancer: an increasing clinical occurrence requiring multidisciplinary management.
肺多发原发癌：发病率逐渐增加并需要多学科综合治疗 OBJECTIVE: No guidelines detailing recommendations for the selection and treatment of patients with synchronous multiple primary lung cancer have been published. We report on a single-institution experience with synchronous multiple primary lung cancer, with emphasis on long-term survival.
目的：没有关于肺多发性原发癌的选择和治疗的详细推荐的指南发表。我们报道关于肺同步多发原发癌单中心经验，强调长期的生存率。
改为：
可供肺多发原发癌病人借鉴的详细诊断治疗指南尚无报道。我们报告本中心关于这种疾病的经验，侧重于长期生存。
METHODS: We performed a retrospective study of 125 consecutive patients with synchronous multiple primary lung cancer who underwent operation between 1985 and 2006. Various treatment strategies were applied, including perioperative therapy. Potential prognosticators were submitted to univariate and multivariate analyses.
方法：我们进行了一项回顾性研究，从1985到2006年共125例连续的肺同步多发原发癌接受手术的患者纳入研究范围。不同的治疗策略被提供给患者，包括手术期间的治疗。通过单变量和多变量分析提供了潜在的预后因子。
改为：
方法：我们回顾性研究了1985到2006年共125例连续手术治疗的肺多发原发癌患者。实施了包括手术期间治疗在内的多种治疗策略。影响预后的潜在因素经单因素和多因素分析。
RESULTS: Tumors were bilateral (n = 34) or ipsilateral (n = 91). Optimal surgical treatment (complete anatomic resection with radical lymphadenectomy) was possible in 65.6% of the cases. pN0 disease was present in 32.3% of the patients; 30-day and 90-day mortality rates were 4.5% and 11%, respectively. Two- and 5-year overall survivals were 61.6% and 34%, respectively, with a median survival of 35 months. On univariate analysis, smoking status, high Charlson index, low forced expiratory volume in 1 second, occurrence of postoperative complications, and performance of a pneumonectomy affected the overall survival adversely. Conversely, bilateral disease, location in the same lobe, and pN0 disease were favorable prognosticators. On multivariate analysis, low forced expiratory volume in 1 second, nonoptimal surgical treatment, and performance of a pneumonectomy were independent predictors of poor long-term survival, whereas female sex, younger age, asymptomatic disease, pN0 status, and performance of an adjuvant treatment affected the survival favorably.
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作者:admin@医学,生命科学 2011-03-06 17:17
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