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【Throax】下肢活力与COPD
Lower limb activity and its determinants in COPD
P P Walker1,2, A Burnett1, P W Flavahan1, P M A Calverley
Background: Patients with chronic obstructive pulmonary disease (COPD) walk less than healthy older people and their self-reported activity predicts exacerbation risk. The relationship between lower limb activity and total daily activity is not known, nor are there any data which relate objectively assessed daily activity to laboratory assessments made before and after rehabilitation.
Methods: Lower limb activity was measured by leg actigraphy over 3 days in 45 patients with moderate to severe COPD and 18 controls of similar age. Thirty-three patients with COPD entered an 8-week rehabilitation programme in which the change in leg activity was measured and related to other outcomes.
Results: In patients with COPD the mean level of activity measured by whole body and leg activity monitors was closely related (r = 0.92; p<0.001), but leg activity was consistently reduced compared with controls of similar age (p = 0.001). Mean leg activity, mean intensity of leg activity and the time that patients spent mobile at home were all related to forced expiratory volume in 1 s (FEV1) (r = 0.57, p = 0.001; r = 0.5, p = 0.003; and r = 0.51, p = 0.002, respectively), but intensity of activity and time spent mobile were not related. Subjects completing pulmonary rehabilitation showed significant improvements in mean activity (p = 0.001) and spent more time moving (p = 0.014). These changes were unrelated to improvement in muscle strength or walking distance but correlated with baseline FEV1 (r = 0.8, p<0.001).
Conclusions: Total daily activity in patients with COPD is closely related to leg activity which is reduced compared with controls of similar age. Individuals differ in the time spent mobile during the day, but subjective and objectively assessed activity improves after rehabilitation and is predicted by FEV1. The change in activity is unrelated to improvements in corridor walking and health status. 认领本文翻译，24小时内未稿其他战友可自由认领。 Thorax 2008;63:683-689
Lower limb activity and its determinants in COPD
P P Walker1,2, A Burnett1, P W Flavahan1, P M A Calverley
肢体低活动力和COPD
P P Walker1,2, A Burnett1, P W Flavahan1, P M A Calverley
Background: Patients with chronic obstructive pulmonary disease (COPD) walk less than healthy older people and their self-reported activity predicts exacerbation risk. The relationship between lower limb activity and total daily activity is not known, nor are there any data which relate objectively assessed daily activity to laboratory assessments made before and after rehabilitation.
背景：患有阻塞性肺疾病（COPD）的患者行走少于健康老人，并且他们自我感觉增加活动是危险的。肢体活动减少和总的日常活动的关系并不明了，也没有任何实验数据客观评估康复前后日常活动的关系。
Methods: Lower limb activity was measured by leg actigraphy over 3 days in 45 patients with moderate to severe COPD and 18 controls of similar age. Thirty-three patients with COPD entered an 8-week rehabilitation programme in which the change in leg activity was measured and related to other outcomes.
方法：低肢体活动力通过三天以上对45名中到中度COPD患者的腿部活动记录检查来完成，对照组为年龄相近的18人。33名COPD病人进入一个8周的康复项目来改善下肢活力并判断和其他结果的关系。
Results: In patients with COPD the mean level of activity measured by whole body and leg activity monitors was closely related (r = 0.92; p<0.001), but leg activity was consistently reduced compared with controls of similar age (p = 0.001). Mean leg activity, mean intensity of leg activity and the time that patients spent mobile at home were all related to forced expiratory volume in 1 s (FEV1) (r = 0.57, p = 0.001; r = 0.5, p = 0.003; and r = 0.51, p = 0.002, respectively), but intensity of activity and time spent mobile were not related. Subjects completing pulmonary rehabilitation showed significant improvements in mean activity (p = 0.001) and spent more time moving (p = 0.014). These changes were unrelated to improvement in muscle strength or walking distance but correlated with baseline FEV1 (r = 0.8, p<0.001).
结果：患有COPD的病人活动的平均值测量显示，全身活动和腿部活动监测密切相关(r = 0.92; p<0.001)，但是腿部活动比对照的同年龄组减少(p = 0.001)。腿部活动的平均值，即腿部活动的强度和在家使用活动装置的时间均与第一秒用力呼气量有关(FEV1) (r = 0.57, p = 0.001; r = 0.5, p = 0.003; and r = 0.51, p = 0.002, 分别地)，但活动强度和使用活动装置的时间无关。被试者彻底肺复原显示平均活动力有显著改善(p = 0.011)并用更多的时间活动。这些改变和肌肉强度改善或行走距离无关，但和FEV1的基线有关(r = 0.8, p<0.001)。
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作者:admin@医学,生命科学 2011-04-18 10:21
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