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【文摘发布】反流和喉炎
Otolaryngology–Head and Neck Surgery (2007) 136, 686-692
Sander Joniau, MD, Anthony Bradshaw, MBBS,
Adrian Esterman, PhD, AStat, and A. Simon Carney, FRACS
OBJECTIVES: To investigate and compare the prevalence of pharyngeal reflux (PR) events in normal controls and patients with clinically diagnosed reflux laryngitis.
METHOD: A systematic review of the literature was performed to identify all prospective studies on the results of 24-hour doubleprobe (pharyngeal and esophageal) pH monitoring in normal controls and in patients with
symptoms and/or signs of reflux laryngitis.
RESULTS: Eleven relevant studies on 192 normal controls and 13 studies on 512 patients with reflux laryngitis were identified. One or more PR events were detected in 51 normal controls (22.9%; 95% CI, 13.9% to
33.3%) and in 154 of 422 patients (38.3%; 95% CI, 25.4% to 52.1%). There is no significant difference in the prevalence of PR events between normal controls and patients with reflux laryngitis (P = 0.079). In addition,
the prevalence of PR events in patients with reflux laryngitis is much lower than reported in previous reviews on this subject.
CONCLUSION: This systematic review calculated that (1) only a minority of patients with clinically diagnosed reflux laryngitis will show PR events, and (2) there is no significant difference between the prevalence of PR
events in patients with reflux laryngitis and healthy controls. At the moment, there is no reliable means to confirm reflux of gastric juice in patients with suspected reflux laryngitis. This diagnostic vacuum is fundamental
and may pose important questions at the current concept of reflux of gastric juice as a common cause of laryngopharyngeal inflammation. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 返流和喉炎
Otolaryngology–Head and Neck Surgery (2007) 136, 686-692
《耳鼻咽喉头颈外科杂志》(2007) 136, 686-692
Sander Joniau, MD, Anthony Bradshaw, MBBS,
Adrian Esterman, PhD, AStat, and A. Simon Carney, FRACS
OBJECTIVES: To investigate and compare the prevalence of pharyngeal reflux (PR) events in normal controls and patients with clinically diagnosed reflux laryngitis.
目的：调查研究咽部返流事件在正常对照组和临床上诊断为返流性喉炎的患者组中的发生频率，并且对两组的发病率进行比较。
METHOD: A systematic review of the literature was performed to identify all prospective studies on the results of 24-hour doubleprobe (pharyngeal and esophageal) pH monitoring in normal controls and in patients with symptoms and/or signs of reflux laryngitis.
方法：许多文献对正常对照组和有返流性喉炎症状和/或体征的患者组的二十四小时可疑指征（咽部和食管）pH值进行监测并得到预期的研究结果。我们对所有这些文献进行系统的回顾性分析，从而对其预期研究结果进行鉴别。
RESULTS: Eleven relevant studies on 192 normal controls and 13 studies on 512 patients with reflux laryngitis were identified. One or more PR events were detected in 51 normal controls (22.9%; 95% CI, 13.9% to 33.3%)
结果：192个正常对照组的11项相关研究和512名返流性喉炎患者的13项研究均经过鉴定。在51名正常对照者中可以检测到一次或更多次的咽部返流事件(22.9%; 95% CI, 13.9% 到33.3%)
and in 154 of 422 patients (38.3%; 95% CI, 25.4% to 52.1%). There is no significant difference in the prevalence of PR events between normal controls and patients with reflux laryngitis (P = 0.079).
并且422名患者中检测到154次咽部反流事件(38.3%; 95% CI, 25.4% to 52.1%)。咽部返流事件的发病率在正常对照组和返流性喉炎患者组之间没有显著的差异性(P = 0.079)。
In addition, the prevalence of PR events in patients with reflux laryngitis is much lower than reported in previous reviews on this subject.
此外，咽部返流事件在返流性喉炎患者的发病率远比以往此类综述报道的要低。
CONCLUSION: This systematic review calculated that (1) only a minority of patients with clinically diagnosed reflux laryngitis will show PR events, and (2) there is no significant difference between the prevalence of PR events in patients with reflux laryngitis and healthy controls.
结论：这项系统的回顾性分析得出适当的结论：(1)仅有一小部分临床上被诊断为返流性喉炎的患者将出现咽部返流事件，并且(2)咽部反流事件在返流性喉炎患者组和健康对照组中的发病率没有显著性差异。
At the moment, there is no reliable means to confirm reflux of gastric juice in patients with suspected reflux laryngitis.
现在还没有可靠的方法来证实可疑的返流性喉炎患者中存在胃液返流现象。
This diagnostic vacuum is fundamental and may pose important questions at the current concept of reflux of gastric juice as a common cause of laryngopharyngeal inflammation.
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作者:admin@医学,生命科学 2011-04-18 10:18
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